1887

Abstract

The duodenal ulcer promoting () gene has been previously described as a risk marker for duodenal ulcer (DU) development and a protective factor against gastric cancer (GC). Recent studies which have assessed the application of in the prediction of clinical outcomes have been controversial. In the current study, the association of with the clinical outcomes and histopathological changes following infection was evaluated in Iranian patients. A total of 157 -infected patients with DU (=30), gastric ulcer (=23), gastritis (=68) or GC (=36) were assessed. The presence of and genes was determined by gene specific PCR. Gastric histopathological changes were recorded according to the updated Sydney system. Seventy-eight (49.7 %) and 71 (45.2 %) of the 157 tested strains, respectively, were positive and negative for both genes. The remaining 8 (5.09 %) of the 157 strains were -positive/-negative. Univariate analysis showed inverse associations between and histological features including dysplasia as the penultimate stage of GC and lymphoid follicles as a consequence of relatively long-standing -associated gastritis. The degrees of nucleotide sequence identity of Iranian strains to Colombian, Brazilian and Indian strains ranged from 86.1 to 100 % for the aligned regions of , from 88  to 98.8 % for and from 93.4  to 99.5 % for the partial sequences of the gene. Despite the fact that possession of the gene showed no association with any disease category in our population as reported in several other countries, association of -negative strains of with pre-malignant lesions calls for additional studies to evaluate the role of this gene as a protective marker against GC.

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2008-05-01
2019-10-18
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