1887

Journal of Medical Microbiology

Volume 57, Issue 3

PorA types in serogroup B isolated in Argentina from 2001 to 2003: implications for the design of an outer membrane protein-based vaccine Free

Abstract

Identification of PorA types remains important, as the PorA protein is a major immunogenic component of several meningococcal vaccines under development. In this study, 191 serogroup B isolates collected in Argentina through active laboratory-based surveillance from 2001 to 2003 were serosubtyped. Nucleotide sequences of the variable region 1 (VR1) and VR2 regions were determined in 52 non-serosubtypeable isolates. A substantial number of distinct VR types were identified, and a new VR2 variant from the P1.16 family was described. This is the first report describing PorA types in serogroup B isolates in Argentina. Furthermore, the wide diversity of subtypes detected by serosubtyping and genosubtyping reveals the difficulty in designing a useful outer-membrane vaccine applicable in this country. A possible mechanism responsible for altered PorA expression was analysed in two PorA types.

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Keyword(s): FSST, fully serosubtyped , INEI, Instituto Nacional de Enfermedades Infecciosas , MenB, Neisseria meningitidis serogroup B , NSST, non-serosubtypeable , OMP, outer-membrane protein , PSST, partially serosubtyped and VR, variable region
© SGM
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2008-03-01
2019-10-18
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PorA types in Neisseria meningitidis serogroup B isolated in Argentina from 2001 to 2003: implications for the design of an outer membrane protein-based vaccine
J. Med. Microbiol. 57, 338 (2008); https://doi.org/10.1099/jmm.0.47631-0
/content/journal/jmm/10.1099/jmm.0.47631-0
/content/journal/jmm/10.1099/jmm.0.47631-0
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