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Volume 57, Issue 4

Distribution of pathogenicity island (SPI)-8 and SPI-10 among different serotypes of Free

Abstract

Many virulence phenotypes of are encoded by genes located on pathogenicity islands. Based on genome analysis, it is predicted that pathogenicity island (SPI)-8 is restricted to serovars Typhi and Paratyphi A, and SPI-10 to serovars Typhi, Paratyphi, Enteritidis, Dublin and Gallinarum. This study was conducted to investigate the distribution of SPI-8 and SPI-10 among isolates from sprouts, fish, water and blood. A total of 110 isolates and 6 serovars from the Microbial Type Culture Collection, Chandigarh, India, were screened. All isolates belonging to serovars Washington, Enteritidis and Paratyphi A had both SPI-8 and SPI-10. All serovar Typhi isolates from water and blood had both SPI-8 and SPI-10, whereas isolates from fish contained only SPI-8. SPI-8 and SPI-10 were also detected in only 3 out of 42 isolates belonging to serovar Typhimurium. Both SPI-8 and SPI-10 were absent in serovars Worthington, Dublin, Paratyphi B and Paratyphi C. These results contradict the predictions from genome sequences available in GenBank and indicate that SPI-8 and SPI-10 are widely distributed among serovars and that virulence factors other than those on SPI-8 and SPI-10 may be responsible for host specificity. This is the first report on the distribution of SPIs in isolates from India.

  • Received:
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Keyword(s): PAI, pathogenicity-associated island and SPI, Salmonella pathogenicity island
Bhabha Atomic Research Centre
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2008-04-01
2024-04-19
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Distribution of Salmonella pathogenicity island (SPI)-8 and SPI-10 among different serotypes of Salmonella
J. Med. Microbiol. 57, 424 (2008); https://doi.org/10.1099/jmm.0.47630-0
/content/journal/jmm/10.1099/jmm.0.47630-0
/content/journal/jmm/10.1099/jmm.0.47630-0
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