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Volume 57, Issue 7

Molecular assessment of invasive serotype 1 in Brazil: evidence of clonal replacement Free

Abstract

In Brazil, serotype 1 is one of the most prevalent causes of severe infection. This study investigated the genetic relatedness of 134 serotype 1 isolates obtained from invasive diseases during the period 1977–2005. Molecular typing by PFGE revealed two major lineages using visual inspection and computer analysis. Type A comprised 94 isolates (70.2 %) with four subtypes, whereas type B comprised 40 isolates (29.8 %) with eight subtypes. Subtype A3, the most frequent genotype, accounting for 65 % of the total isolates, was identified as a representative of clone Sweden-40 (ST304). Type B was predominant in the period 1977–1988. In contrast, an increase in the type A lineage was detected from 1990 in Brazil, significantly associated with isolates recovered from pneumonia cases and from young patients. This study clearly established a temporal switch between two lineages of serotype 1 in Brazil, with a wide dispersion of clone Sweden-40 in recent years.

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Keyword(s): CI, confidence interval , MLST, multilocus sequence typing , OR, odds ratio and SC, Dice similarity coefficient
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2008-07-01
2024-04-25
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Molecular assessment of invasive Streptococcus pneumoniae serotype 1 in Brazil: evidence of clonal replacement
J. Med. Microbiol. 57, 839 (2008); https://doi.org/10.1099/jmm.0.47612-0
/content/journal/jmm/10.1099/jmm.0.47612-0
/content/journal/jmm/10.1099/jmm.0.47612-0
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