1887

Abstract

species are emerging opportunistic pathogens capable of causing chronic lung infections in cystic fibrosis patients. This study examined the interactions of 17 isolates from the five identified species ( , , , and ) plus two genomospecies isolates with lung epithelial cells and their ability to form biofilms . Only three isolates showed an ability to invade A549 lung epithelial cells, and only one isolate was able to form biofilms. In contrast, all isolates triggered a pronounced pro-inflammatory response, with elevation of both interleukin (IL)-6 (two- to 19-fold) and IL-8 (10- to 50-fold) above that observed for a control strain of . This property is likely to be a major factor in the pathogenesis of the genus.

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2008-01-01
2019-09-17
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