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1887

Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 57, Issue 1

Evaluation of virulence characteristics of the genus in lung epithelial cells No Access

Abstract

species are emerging opportunistic pathogens capable of causing chronic lung infections in cystic fibrosis patients. This study examined the interactions of 17 isolates from the five identified species ( , , , and ) plus two genomospecies isolates with lung epithelial cells and their ability to form biofilms . Only three isolates showed an ability to invade A549 lung epithelial cells, and only one isolate was able to form biofilms. In contrast, all isolates triggered a pronounced pro-inflammatory response, with elevation of both interleukin (IL)-6 (two- to 19-fold) and IL-8 (10- to 50-fold) above that observed for a control strain of . This property is likely to be a major factor in the pathogenesis of the genus.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Bcc, Burkholderia cepacia complex , CF, cystic fibrosis , IL, interleukin and MBC, minimum bactericidal concentration
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/content/journal/jmm/10.1099/jmm.0.47544-0
2008-01-01
2025-01-19
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/content/journal/jmm/10.1099/jmm.0.47544-0
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Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells
J. Med. Microbiol. 57, 15 (2008); https://doi.org/10.1099/jmm.0.47544-0
/content/journal/jmm/10.1099/jmm.0.47544-0
/content/journal/jmm/10.1099/jmm.0.47544-0
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