1887

Abstract

The objective of this study was to determine the prevalence and genetic variability of human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted infections (STIs) among 205 patients with clinical diagnosis of tuberculosis (TB) in Buenos Aires in 2001. Infections with hepatitis B virus (HBV), HIV-1, hepatitis C virus (HCV), and human T-cell lymphotropic virus types I/II were diagnosed in 37/187 (19.8 %), 35/205 (17.1 %), 22/187 (11.8 %), 13/187 (7.0 %) and 4/181 (2.2 %) patients, respectively. Almost one in three participants (33.1 %) presented at least one infection in addition to TB. Multiresistance to TB drugs (isoniazid plus rifampicin) was detected in the isolates recovered from three patients. Injecting drug use was detected as the main risk factor for HIV, HBV and HCV infections. Of ten patients who died, eight were infected with HIV. HIV genetic characterization showed the presence of two different subtypes. Env subtype F was found in 13/24 samples (54.2 %) and subtype B in 11/24 samples (45.8 %) by heteroduplex mobility assay. Sequencing of the protease/RT region was performed in ten samples: three were characterized as subtype B and seven as B/F recombinants by bootscanning analysis. Phylogenetic analysis of four full-length sequences showed that three were the circulating recombinant form CRF12_BF. The results of this study suggest an urgent need to detect HIV infection in high-risk groups to prevent future HIV transmission as well as morbidity and mortality associated with TB by providing highly active antiretroviral therapy (HAART) and/or TB treatment. Collaboration between TB and HIV programmes seems to be the best approach to decrease the incidence of these diseases, especially in high-prevalence HIV settings.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.47492-0
2008-02-01
2019-10-13
Loading full text...

Full text loading...

/deliver/fulltext/jmm/57/2/190.html?itemId=/content/journal/jmm/10.1099/jmm.0.47492-0&mimeType=html&fmt=ahah

References

  1. Aaron, L., Saadoun, D., Calatroni, I., Launay, O., Mémain, N., Vincent, V., Marchal, G., Dupont, B., Bouchaud, O. & other authors ( 2004; ). Tuberculosis in HIV-infected patients: a comprehensive review. Clin Microbiol Infect 10, 388–398.[CrossRef]
    [Google Scholar]
  2. Ávila, M. M., Pando, M. A., Carrión, G., Martínez Peralta, L., Salomón, H., Gómez Carrillo, M., Sánchez, J., Maulen, S., Hierholzer, J. & other authors ( 2002; ). Two epidemics in Argentina: different genetic subtypes associated with different risk groups. J Acquir Immune Defic Syndr 29, 422–426.[CrossRef]
    [Google Scholar]
  3. Carr, J. K., Ávila, M. M., Gómez Carrillo, M., Salomón, H., Hierholzer, J., Watanaveeradej, V., Pando, M. A., Negrete, M., Russell, K. L. & other authors ( 2001; ). Diverse BF recombinants have spread widely since the introduction of HIV-1 into South America. AIDS 15, F41–F47.[CrossRef]
    [Google Scholar]
  4. CDC ( 2006; ). Trends in tuberculosis – United States, 2005. MMWR Morb Mortal Wkly Rep 55, 305–308.
    [Google Scholar]
  5. Delwart, E. L., Shpaer, E. G., Louwagie, J., McCutchan, F. E., Grez, M., Rübsamen-Waigmann, H. & Mullins, J. I. ( 1993; ). Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes. Science 262, 1257–1261.[CrossRef]
    [Google Scholar]
  6. Dye, C. ( 2006; ). Global epidemiology of tuberculosis. Lancet 367, 938–940.[CrossRef]
    [Google Scholar]
  7. Espinosa, A., Vignoles, M., Carrillo, M. G., Sheppart, H., Donovan, R., Peralta, L. M., Rossi, D., Radulich, G., Salomón, H. & Weissenbacher, M. ( 2004; ). Intersubtype BF recombinants of HIV-1 in a population of injecting drug users in Argentina. J Acquir Immune Defic Syndr 36, 630–636.[CrossRef]
    [Google Scholar]
  8. Frieden, T. R., Sterling, T. R., Munsiff, S. S., Watt, C. J. & Dye, C. ( 2003; ). Tuberculosis. Lancet 362, 887–899.[CrossRef]
    [Google Scholar]
  9. Frothingham, R., Stout, J. E. & Hamilton, C. D. ( 2005; ). Current issues in global tuberculosis control. Int J Infect Dis 9, 297–311.[CrossRef]
    [Google Scholar]
  10. Liga Argentina Contra la Tuberculosis ( 2003; ). Situación de la Tuberculosis Republica Argentina, 2002. Revista Argentina del Tórax 64. Available at http://www.lalat.org.ar/revista/vol64/actualizacion.htm.
    [Google Scholar]
  11. Lole, K. S., Bollinger, R. C., Paranjape, R. S., Gadkari, D., Kulkarni, S. S., Novak, N. G., Ingersoll, R., Sheppard, H. W. & Ray, S. C. ( 1999; ). Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol 73, 152–160.
    [Google Scholar]
  12. Moscatello, G., Campello, P. & Benetucci, J. A. ( 2003; ).Bloodborne and sexually transmitted infections in drug users in a hospital in Buenos Aires, Argentina. Clin Infect Dis 37 (Suppl. 5), S343–347
    [Google Scholar]
  13. Musella, R. M., Castagnino, J. P., Weber, L., Boxaca, M. C., Weissenbacher, M. C., Abbate, E. H. & González Montaner, L. J. ( 1990; ).Human immunodeficiency virus infection associated with tuberculosis. Medicina (B Aires) 50, 3–8 (in Spanish).
    [Google Scholar]
  14. Palmero, D., Ritacco, V., Ambroggi, M., Poggi, S., Guemes Gurtabay, J., Alberti, F. & Waisman, J. ( 2006; ). Multidrug-resistant tuberculosis in AIDS patients at the beginning of the millennium. Medicina (B Aires) 66, 399–404 (in Spanish).
    [Google Scholar]
  15. Pando, M. A., Maulen, S., Weissenbacher, M., Marone, R., Duranti, R., Peralta, L. M., Salomón, H., Russell, K., Negrete, M. & other authors ( 2003; ). High HIV-1 seroprevalence in men who have sex with men in Buenos Aires, Argentina: risk factors for infection. Int J Epidemiol 32, 735–740.[CrossRef]
    [Google Scholar]
  16. Pando, M. A., Biglione, M. M., Toscano, M. F., Rey, J., Russell, K. L., Negrete, M., Gianni, S., Martínez-Peralta, L., Salomón, H. & other authors ( 2004; ). Human immunodeficiency virus type 1 and other viral co-infections among young heterosexual men and women in Argentina. Am J Trop Med Hyg 71, 153–159.
    [Google Scholar]
  17. Pando, M. A., Berini, C., Bibini, M., Fernández, M., Reinaga, E., Maulen, S., Marone, R., Biglione, M., Sánchez, J. & other authors ( 2006; ). Prevalence of HIV-1 and other sexually transmitted infections among female commercial sex workers in Argentina. Am J Trop Med Hyg 74, 233–238.
    [Google Scholar]
  18. Putruele, A. M., Limongi, L. F., Legarreta, C. G., Martínez, P. R., Davidovich, A. & Kempf, N. ( 2006; ). Evaluación diagnóstica y tratamiento en 457 casos de tuberculosis. Abstracts of the 11th International Internal Medicine Congress of the Hospital de Clínicas. Medicina (B Aires) 66 (Suppl. 1), 3 (in Spanish).
    [Google Scholar]
  19. Reid, A., Scano, F., Getahun, H., Williams, B., Dye, C., Nunn, P., De Cock, K. M., Hankins, C., Miller, B. & other authors ( 2006; ). Towards universal access to HIV prevention, treatment, care, and support: the role of tuberculosis/HIV collaboration. Lancet Infect Dis 6, 483–495.[CrossRef]
    [Google Scholar]
  20. Weissenbacher, M., Rossi, D., Radulich, G., Sosa-Estáni, S., Vila, M., Vivas, E., Avila, M. M., Cuchi, P., Rey, J. & Peralta, L. M. ( 2003; ). High seroprevalence of bloodborne viruses among street recruited injection drug users from Buenos Aires, Argentina. Clin Infect Dis 37 (Suppl. 5), S348–S352.[CrossRef]
    [Google Scholar]
  21. WHO ( 2002; ). Global Tuberculosis Control: Surveillance, Planning, Financing. Available at http://www.who.int/tb/publications/global_report/en/. Geneva: World Health Organization.
  22. WHO ( 2006; ). Tuberculosis. Fact sheet no. 104. Revised March 2007. http://www.who.int/mediacentre/factsheets/fs104/en/print.html. Last access November 2006. Geneva: World Health Organization.
  23. WHO/IUATLD ( 2004; ). Project on Anti-tuberculosis Drug Resistance Surveillance. Anti-tuberculosis Drug Resistance in the World. Report no. 3. WHO/TB 99.269. Geneva: World Health Organization.
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.47492-0
Loading
/content/journal/jmm/10.1099/jmm.0.47492-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error