1887

Abstract

The development of tuberculosis (TB) infection in humans depends on the mycobacterial strain and the human host, and is multigenically controlled in both. ATP ligation of P2X receptors expressed on human macrophages infected with mycobacteria induces cell death and subsequent loss of intracellular bacterial viability. This study analysed the allelic distribution of two single-nucleotide polymorphisms (SNPs) in the gene in the Slavic population of the St Petersburg area of Russia. Analysis of the −762 C/T promoter SNP revealed no significant association between pulmonary TB patients and control subjects (3×2 =3.2, 1 d.f., =0.2). The −762C allele was highly and almost equally represented in both groups in this study (68.2 % in patients and 69.3 % in controls). This result differs strikingly from a Gambian study where this allele was found in only 7 and 12 % of pulmonary TB patients and controls, respectively [Li, C. M., Campbell, S. J., Kumararatne, D. S., Bellamy, R., Ruwende, C., McAdam, K. P. W. J., Hill, A. V. S. & Lammas, D. A. (2002). , 1458–1462]. In contrast, the frequency of the C allele at position 1513 in exon 13, resulting in a loss of P2X function, was significantly higher among pulmonary TB patients in this study (=0.02). Thus, analysis of the P2X receptor gene in the Russian Slavic population showed that the 1513C allele, acting dominantly, is a possible risk factor for clinical TB, whereas the −762 polymorphism did not appear to be associated with human susceptibility to TB.

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2008-05-01
2019-10-15
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vol. , part 5, pp. 581 - 584

Results of stratification analysis for the -762 and 1513 genotypes and alleles. [PDF](19 KB)



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