1887

Abstract

Lipopolysaccharide (LPS) is a major surface component of , as with all Gram-negative bacteria. The effect of LPS on infectivity of human epithelial cells was investigated. LPS and LPS antibody significantly reduced infectivity, mostly in a dose-dependent manner. As the structure of LPS in is simple and consists only of lipid A and 3-deoxy--manno-octulosonic acid (Kdo), we investigated whether lipid A or Kdo was inhibitory to chlamydial infectivity. Polymyxin B, as a lipid A inhibitor, and Kdo considerably reduced infectivity. With all the LPS inhibitors used, there was greater inhibition against serovar E than serovar LGV. These results suggest a role for LPS in chlamydial infectivity. Elucidation of how LPS acts in infectivity and identification of host-cell receptors would help in understanding pathogenicity.

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2008-03-01
2024-12-06
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