1887

Abstract

The aims of the study were to evaluate the incidence of and in untreated Bulgarian children from 1996 to 2006, to analyse the performance of diagnostic tests, and to look at density in specimens by culture. Antral specimens from children with chronic gastritis (=513), peptic ulcers (=54) and other diseases (=91) were evaluated by direct Gram staining (DGS), in-house rapid urease test (RUT) and culture. The living environment and semi-quantitative density were assessed in 188 and 328 children, respectively. infection was found in children with ulcers (77.8  %), chronic gastritis (64.5  %) and other diseases (36.3  %). Half (51.4  %) of patients aged 1–5 years and 77.4  % of those aged 16–17 years were -positive. Of all children, 328 (49.8  %) showed positive DGS, 184 (28  %) had a positive RUT, and 386 (58.7  %) were culture-positive. Unlike gastric mucus specimens, frozen biopsy specimens provided reliable diagnosis. was observed in two (0.3  %) children. High density (growth into all quadrants of plates) was found in 18  % of 328 children evaluated, involving 31  % of ulcer and 16.7  % of non-ulcer patients. infection was more common in rural children with chronic gastritis (91.3  %) than in the remainder (66.7  %). In conclusion, infection was common in symptomatic Bulgarian children. The infection prevalence was >77  % in patients aged 16–17 years, in children with a duodenal ulcer, and in rural patients. infection was uncommon. The performance of the bacterial culture was good. The impact of density on the clinical expression and eradication of the infection requires further evaluation. The results highlight the need for routine diagnosis in rural children with chronic gastritis.

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2007-08-01
2019-11-13
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