A cross-reactive neisserial antigen encoded by the NMB0035 locus shows high sequence conservation but variable surface accessibility

References

1. Adu-Bobie J., Capecchi B., Senisto D., Rappouli R., Pizza M. 2003; Two years into reverse vaccinology. Vaccine 21:605–610 [CrossRef]
   [Google Scholar]
2. Arenas J. A., Abel A., Sánchez S., Alcalá B., Criado M. T., Ferreirós C. M. 2006; Locus NMB0035 codes for a 47 kDa surface-accessible conserved antigen in Neisseria . Int Microbiol 9:273–280
   [Google Scholar]
3. Beitz E. 2000; TeXshade: shading and labeling of multiple sequence alignment using LaTeX2e. Bioinformatics 16:135–139 [CrossRef]
   [Google Scholar]
4. Bowden R. A., Cloeckaert A., Zygmunt M. S., Bernard S., Dubray G. 1995; Surface exposure of outer membrane protein and lipopolysaccharide epitopes in Brucella species studied by enzyme-linked immunosorbent assay and flow cytometry. Infect Immun 63:3945–3952
   [Google Scholar]
5. Doytchinova I. A., Flower D. R. 2002; Quantitative approaches to computational vaccinology. Immunol Cell Biol 80:270–279 [CrossRef]
   [Google Scholar]
6. Gorringe A. R., Halliwell D., Matheson M., Reddin K., Finney M., Hudson M. 2005; The development of a meningococcal disease vaccine based on Neisseria lactamica outer membrane vesicles. Vaccine 23:2210–2213 [CrossRef]
   [Google Scholar]
7. Gorter A. D., Oostrikb J., van der Ley P., Hiemstrac P. S., Dankerta J., van Alphen L. 2003; Involvement of lipooligosaccharides of Haemophilus influenzae and Neisseria meningitidis in defensin-enhanced bacterial adherence to epithelial cells. Microb Pathog 34:121–130 [CrossRef]
   [Google Scholar]
8. Huang X., Madan A. 1999; cap3: a DNA sequence assembly program. Genome Res 9:868–877 [CrossRef]
   [Google Scholar]
9. Jolley K. A., Appleby L., Wright J. C., Christoloulides M., Heckels J. E. 2001; Immunization with recombinant Opc outer membrane protein from Neisseria meningitidis : influence of sequence variation and levels of expression on the bactericidal immune response against meningococci. Infect Immun 69:3809–3816 [CrossRef]
   [Google Scholar]
10. Kahler C. M., Datta A., Tzeng Y. L., Carlson R. W., Stephens D. S. 2005; Inner core assembly and structure of the lipooligosaccharide of Neisseria meningitidis : capacity of strain NMB to express all known immunotype epitopes. Glycobiology 15:409–419
    [Google Scholar]
11. Khan A. S., Mujer C. V., Alefantis T. G., Connolly J. P., Mayr V. B., Walcher P., Lubilz W., DelVecchio U. G. 2006; Proteomics and bioinformatics strategies to design countermeasures against infectious threat agents. J Chem Inf Model 46:111–115 [CrossRef]
    [Google Scholar]
12. Kumar S., Tamura K., Nei M. 2004; mega3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 5:150–163 [CrossRef]
    [Google Scholar]
13. Leclerc C. L. 2003; New approaches in vaccine development. Comp Immunol Microbiol Infect Dis 26:329–341 [CrossRef]
    [Google Scholar]
14. Martin S. L., Borrow R., van der Ley P., Dawson M., Fox A. J., Cartwright K. A. 2000; Effect of sequence variation in meningococcal PorA outer membrane protein on the effectiveness of a hexavalent PorA outer membrane vesicle vaccine. Vaccine 18:2476–2481 [CrossRef]
    [Google Scholar]
15. Michaelsen T. E., Aase A., Kolberg J., Wedege E., Rosenqvist E. 2001; PorB3 outer membrane protein on Neisseria meningitidis is poorly accessible for antibody binding on live bacteria. Vaccine 19:1526–1533 [CrossRef]
    [Google Scholar]
16. Morley S. L., Pollard A. J. 2001; Vaccine prevention of meningococcal disease, coming soon?. Vaccine 20:666–687 [CrossRef]
    [Google Scholar]
17. Morley S. L., Cole M. J., Ison C. A., Camaraza M. A., Sotolongo M., Anwar N., Cuevas I., Carbonero M., Campa H. C. other authors 2001; Immunogenicity of a serogroup B meningococcal vaccine against multiple Neisseria meningitidis strains in infants. Pediatr Infect Dis J 20:1054–1061 [CrossRef]
    [Google Scholar]
18. O'Dwyer C. A., Reddin K., Martin D., Taylor S. C., Gorringe A. R., Hudson M. J., Brodeur B. R., Langford P. R., Kroll J. S. 2004; Expression of heterologous antigens in commensal Neisseria spp.: preservation of conformational epitopes with vaccine potential. Infect Immun 72:6511–6518 [CrossRef]
    [Google Scholar]
19. Petrovsky N., Brusic V. 2002; Computational immunology: the coming of age. Immunol Cell Biol 80:248–254 [CrossRef]
    [Google Scholar]
20. Pintor M., Ferrón L., Gómez J. A., Powell N. B. L., Ala'Aldeen D. A. A., Borrriello S. P., Criado M. T., Ferreirós C. M. 1996; Blocking of iron uptake from transferrin by antibodies against the transferrin binding proteins in Neisseria meningitidis . Microb Pathog 20:127–139 [CrossRef]
    [Google Scholar]
21. Rosenqvist E., Hoiby E. A., Wedege E., Bryn K., Kolberg J., Klem A., Ronnild E., Bjune G., Nokleby H. 1995; Human antibody responses to meningococcal outer membrane antigens after three doses of the Norwegian group B meningococcal vaccine. Infect Immun 63:4642–4652
    [Google Scholar]
22. Steeghs L., de Cock H., Evers E., Zomer B., Tommassen J., van der Ley P. 2001; Outer membrane composition of a lipopolysaccharide-deficient Neisseria meningitidis mutant. EMBO J 20:6937–6945 [CrossRef]
    [Google Scholar]
23. Tappero J. W., Lagos R., Ballesteros A. M., Plikaytis B., Williams D., Dykes J., Gheesling L. L., Carlone G. M., Hoiby E. A. other authors 1999; Immunogenicity of 2 serogroup B outer-membrane protein meningococcal vaccines: a randomized controlled trial in Chile. JAMA 281:1520–1527
    [Google Scholar]
24. Troncoso G., Sánchez S., Moreda M., Criado M. T., Ferreirós C. M. 2000; Antigenic cross-reactivity between outer membrane proteins of Neisseria meningitidis and commensal Neisseria species. FEMS Immunol Med Microbiol 27:103–109 [CrossRef]
    [Google Scholar]
25. Valdivia R. H., Falkow S. 1998; Flow cytometry and bacterial pathogenesis. Curr Opin Microbiol 1:359–363 [CrossRef]
    [Google Scholar]
26. Van de Peer Y., De Wachter R. 1994; treecon for Windows: a software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment. Comput Appl Biosci 10:569–570
    [Google Scholar]
27. Welsch J. A., Moe G. R., Rossi R., Adu-Bobie J., Rappouli R., Granoff D. M. 2003; Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity. J Infect Dis 188:1730–1740 [CrossRef]
    [Google Scholar]
28. Williams J. N., Skipp P. J., Humphries H. E., Christodoulides M., O'Connor C. D., Heckels J. E. 2007; Proteomic analysis of outer membranes and vesicles from wild-type serogroup B Neisseria meningitidis and a lipopolysaccharide-deficient mutant. Infect Immun 75:1364–1372 [CrossRef]
    [Google Scholar]
29. Yu K., Petrovsky Y. K., Schönbach C., Koh J. Y., Brusic V. 2002; Methods for prediction of peptide binding to MHC molecules: a comparative study. Mol Med 8:137–148
    [Google Scholar]
30. Zagursky R. J., Rusell D. 2001; Bioinformatics: use in bacterial vaccine discovery. Biotechniques 31:636–640
    [Google Scholar]
31. Zhang C., Anderson A., DeLisi C. 1998; Structural principles that govern the peptide-binding motifs of class I MHC molecules. J Mol Biol 281:929–947 [CrossRef]
    [Google Scholar]
32. Zhu P., Klutch M. J., Bash M. C., Tsang R. S. W., Ng L., Tsai C. 2002; Genetic diversity of three lgt loci for biosynthesis of lipooligosaccharide (LOS) in Neisseria species. Microbiology 148:1833–1844
    [Google Scholar]