1887

Abstract

The involvement of oral bacteria in the pathogenesis of cardiovascular disease has been studied, with , a pathogen of dental caries, detected in cardiovascular lesions at a high frequency. However, no information is available regarding the properties of detected in those lesions. Heart valve specimens were collected from 52 patients and atheromatous plaque specimens from 50 patients, all of whom underwent cardiovascular operations, and dental plaque specimens were taken from 41 of those subjects prior to surgery. Furthermore, saliva samples were taken from 73 sets of healthy mothers (=73) and their healthy children (=78). Bacterial DNA was extracted from all specimens, then analysed by PCR with -specific and serotype-specific primer sets. The detection rates of in the heart valve and atheromatous plaque specimens were 63 and 64 %, respectively. Non- serotypes were identified with a significantly higher frequency in both cardiovascular and dental plaque samples from the subjects who underwent surgery as compared to serotype , which was detected in 70–75 % of the samples from the healthy subjects. The serotype distribution in cardiovascular patients was significantly different from that in healthy subjects, suggesting that serotype may be related to cardiovascular disease.

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2007-04-01
2019-12-13
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