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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 56, Issue 5

colonizes but does not often disseminate from the mouse caecum No Access

Abstract

is the second or third most frequent cause of candidaemia. The gastrointestinal tract is considered to be a major portal of entry for systemic candidiasis, but relatively few studies have investigated the pathogenesis of . Experiments were designed to clarify the ability of to disseminate from the mouse intestinal tract. Following oral inoculation, readily colonized the caeca [approx. 10 cells (g caecum)] of antibiotic-treated mice, but extraintestinal dissemination was not detected. Superimposing several mouse models of trauma and/or immunosuppression known to induce dissemination of and other intestinal microbes did not cause to disseminate often, although one exception was mice given high doses of dexamethasone for 4 days. These data support the hypothesis that the antibiotic-treated mouse intestine may be an epidemiological reservoir for and that this yeast tends to disseminate under specific clinical conditions.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): i.p., intraperitoneally and MLNs, mesenteric lymph nodes
SGM
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2007-05-01
2025-05-16
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Candida glabrata colonizes but does not often disseminate from the mouse caecum
J. Med. Microbiol. 56, 688 (2007); https://doi.org/10.1099/jmm.0.47049-0
/content/journal/jmm/10.1099/jmm.0.47049-0
/content/journal/jmm/10.1099/jmm.0.47049-0
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