1887

Abstract

is the second or third most frequent cause of candidaemia. The gastrointestinal tract is considered to be a major portal of entry for systemic candidiasis, but relatively few studies have investigated the pathogenesis of . Experiments were designed to clarify the ability of to disseminate from the mouse intestinal tract. Following oral inoculation, readily colonized the caeca [approx. 10 cells (g caecum)] of antibiotic-treated mice, but extraintestinal dissemination was not detected. Superimposing several mouse models of trauma and/or immunosuppression known to induce dissemination of and other intestinal microbes did not cause to disseminate often, although one exception was mice given high doses of dexamethasone for 4 days. These data support the hypothesis that the antibiotic-treated mouse intestine may be an epidemiological reservoir for and that this yeast tends to disseminate under specific clinical conditions.

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2007-05-01
2019-11-14
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