%0 Journal Article %A Ishida, Ikuo %A Kohda, Chikara %A Yanagawa, Yoko %A Miyaoka, Hideyo %A Shimamura, Tadakatsu %T Epigallocatechin gallate suppresses expression of receptor activator of NF-κB ligand (RANKL) in Staphylococcus aureus infection in osteoblast-like NRG cells %D 2007 %J Journal of Medical Microbiology, %V 56 %N 8 %P 1042-1046 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.47029-0 %K TNF, tumour necrosis factor %K TLR, Toll-like receptor %K RANKL, receptor activator of NF-κB ligand %K IL, interleukin %K EGCg, epigallocatechin gallate %I Microbiology Society, %X Catechin, a constituent of tea, possesses various bioactivities. In particular, the most abundant catechin in tea is epigallocatechin gallate (EGCg), which has an anti-inflammatory effect. In the present study, the usability of EGCg for osteomyelitis treatment was examined. Osteomyelitis is a difficult disease to cure, partly due to bone lysis caused by infected osteoblasts. Since bone lysis is promoted by proinflammatory cytokines and the receptor activator of NF-κB ligand (RANKL), osteoblasts were infected with Staphylococcus aureus and the effect of EGCg on the production of cytokines was examined. It was found that the production of interleukin 6 and RANKL was suppressed in the osteoblasts treated with EGCg, which indicated an inflammation suppression effect of EGCg in osteomyelitis treatment. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47029-0