@article{mbs:/content/journal/jmm/10.1099/jmm.0.47029-0, author = "Ishida, Ikuo and Kohda, Chikara and Yanagawa, Yoko and Miyaoka, Hideyo and Shimamura, Tadakatsu", title = "Epigallocatechin gallate suppresses expression of receptor activator of NF-κB ligand (RANKL) in Staphylococcus aureus infection in osteoblast-like NRG cells", journal= "Journal of Medical Microbiology", year = "2007", volume = "56", number = "8", pages = "1042-1046", doi = "https://doi.org/10.1099/jmm.0.47029-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47029-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "TNF, tumour necrosis factor", keywords = "TLR, Toll-like receptor", keywords = "RANKL, receptor activator of NF-κB ligand", keywords = "IL, interleukin", keywords = "EGCg, epigallocatechin gallate", abstract = "Catechin, a constituent of tea, possesses various bioactivities. In particular, the most abundant catechin in tea is epigallocatechin gallate (EGCg), which has an anti-inflammatory effect. In the present study, the usability of EGCg for osteomyelitis treatment was examined. Osteomyelitis is a difficult disease to cure, partly due to bone lysis caused by infected osteoblasts. Since bone lysis is promoted by proinflammatory cytokines and the receptor activator of NF-κB ligand (RANKL), osteoblasts were infected with Staphylococcus aureus and the effect of EGCg on the production of cytokines was examined. It was found that the production of interleukin 6 and RANKL was suppressed in the osteoblasts treated with EGCg, which indicated an inflammation suppression effect of EGCg in osteomyelitis treatment.", }