1887

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Volume 56, Issue 8

Epigallocatechin gallate suppresses expression of receptor activator of NF-B ligand (RANKL) in infection in osteoblast-like NRG cells Free

Abstract

Catechin, a constituent of tea, possesses various bioactivities. In particular, the most abundant catechin in tea is epigallocatechin gallate (EGCg), which has an anti-inflammatory effect. In the present study, the usability of EGCg for osteomyelitis treatment was examined. Osteomyelitis is a difficult disease to cure, partly due to bone lysis caused by infected osteoblasts. Since bone lysis is promoted by proinflammatory cytokines and the receptor activator of NF-B ligand (RANKL), osteoblasts were infected with and the effect of EGCg on the production of cytokines was examined. It was found that the production of interleukin 6 and RANKL was suppressed in the osteoblasts treated with EGCg, which indicated an inflammation suppression effect of EGCg in osteomyelitis treatment.

  • Received:
  • Accepted:
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Keyword(s): EGCg, epigallocatechin gallate , IL, interleukin , RANKL, receptor activator of NF-κB ligand , TLR, Toll-like receptor and TNF, tumour necrosis factor
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2007-08-01
2023-06-02
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Epigallocatechin gallate suppresses expression of receptor activator of NF-κB ligand (RANKL) in Staphylococcus aureus infection in osteoblast-like NRG cells
J. Med. Microbiol. 56, 1042 (2007); https://doi.org/10.1099/jmm.0.47029-0
/content/journal/jmm/10.1099/jmm.0.47029-0
/content/journal/jmm/10.1099/jmm.0.47029-0
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