1887

Abstract

Cells of strain A5 adhered to plasticized polyvinyl chloride catheter tubing and grew at low nutrient concentration, consistent with reports of catheter-associated infection. Starting with initial cell densities of 1–2×10 c.f.u. ml, biofilms of approximately 350 c.f.u. cm formed within 24 h at room temperature. Growth rates of cells in biofilms were exponential and equal to 2.45 days doubling time. Rates were exponential for 1–2 weeks incubation and reached cell densities of 6.5×10 c.f.u. cm by 4 weeks. Cells grown in catheter biofilms were significantly more resistant to clarithromycin and rifamycin than cells grown in suspension.

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2007-02-01
2019-10-13
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