1887

Abstract

To assess the prevalence of cytolethal distending toxin (CDT) among Shiga toxin-producing (STEC), 202 STEC strains were investigated using PCRs targeting various alleles ( to ). Seven of the 202 strains contained and an additional seven contained . All 14 -positive strains produced biologically active CDT, as demonstrated by a progressive distension of cultured Chinese hamster ovary cells. The CDT-positive STEC belonged to eight different serotypes, including sorbitol-fermenting O157 : NM (non-motile). The data demonstrate that CDT is present in some STEC serotypes only. However, more studies are required to evaluate whether CDT presence is associated with severe disease.

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2006-11-01
2019-10-14
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