1887

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Volume 55, Issue 11

Cytolethal distending toxins in Shiga toxin-producing : alleles, serotype distribution and biological effects Free

Abstract

To assess the prevalence of cytolethal distending toxin (CDT) among Shiga toxin-producing (STEC), 202 STEC strains were investigated using PCRs targeting various alleles ( to ). Seven of the 202 strains contained and an additional seven contained . All 14 -positive strains produced biologically active CDT, as demonstrated by a progressive distension of cultured Chinese hamster ovary cells. The CDT-positive STEC belonged to eight different serotypes, including sorbitol-fermenting O157 : NM (non-motile). The data demonstrate that CDT is present in some STEC serotypes only. However, more studies are required to evaluate whether CDT presence is associated with severe disease.

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  • Accepted:
  • Published Online:
Keyword(s): CDT, cytolethal distending toxin , CHO, Chinese hamster ovary , HUS, haemolytic uraemic syndrome , NM, non-motile , NSF, non-sorbitol fermenting , SF, sorbitol fermenting and STEC, Shiga toxin-producing Escherichia coli
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2006-11-01
2024-04-20
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Cytolethal distending toxins in Shiga toxin-producing Escherichia coli: alleles, serotype distribution and biological effects
J. Med. Microbiol. 55, 1487 (2006); https://doi.org/10.1099/jmm.0.46666-0
/content/journal/jmm/10.1099/jmm.0.46666-0
/content/journal/jmm/10.1099/jmm.0.46666-0
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