1887

Abstract

is associated with gastric disorders in humans and some experimental animals, and possesses the /type 2 autoinducer (AI-2) system. The effects of a specific mutation on the characteristics of were examined. On 0.3 % agar medium, motility of HPKY08 ( : : ) was significantly lower than that of wild-type TK1402. The -complemented strain HPKY21 exhibited motility comparable to that of TK1402. It was shown that the /AI-2 system plays an important role in motility. The mutant exhibited a reduced infection rate relative to the wild-type parent strain TK1402 in a Mongolian gerbil model. At 3 months after oral inoculation, lower numbers of were detected by semi-quantitative real-time reverse transcription PCR (qRT-PCR) in mutant-infected gerbils than in TK1402-infected gerbils. Gastric inflammation and increased antibody titre for were observed in TK1402-infected gerbils only.

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2006-11-01
2020-10-22
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