-associated oxidant monochloramine induces reactivation of Epstein–Barr virus (EBV) in gastric epithelial cells latently infected with EBV Free

Abstract

To investigate the possibility of an interaction between two ubiquitous human pathogens, and Epstein–Barr virus (EBV), the effect of monochloramine (NHCl), locally produced by infection, on gastric epithelium latently infected with EBV was examined, by assessing the induction of EBV lytic infection. AGS cells harbouring latently infected EBV were used as the indicator of lytic change caused by NHCl treatment. Lytic infection, determined by morphological change and EA-D antigen expression, occurred immediately after treatment with -synthesized NHCl. Analysis of EBV infection in human gastric tissue revealed that out of 48 -positive patients, 24 were positive for EBER-1, and 18 and 13 were positive for EBNA1 and LMP-1 antigen, respectively. The results suggest that -associated NHCl induces EBV lytic conversion in gastric epithelium latently infected with EBV.

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2006-07-01
2024-03-29
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References

  1. Asahi M., Azuma T., Ito S. & 9 other authors; 2000; Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med 191:593–602 [CrossRef]
    [Google Scholar]
  2. Cayrol C., Flemington E. 1996; G0/G1 growth arrest mediated by a region encompassing the basic leucine zipper (bZIP) domain of the Epstein–Barr virus transactivator Zta. J Biol Chem 271:31799–31802 [CrossRef]
    [Google Scholar]
  3. Faulkner G. C., Krajewski A. S., Crawford D. H. 2000; The ins and outs of EBV infection. Trends Microbiol 8:185–189 [CrossRef]
    [Google Scholar]
  4. Fukayama M., Hayashi Y., Iwasaki Y. & 7 other authors; 1994; Epstein–Barr virus-associated gastric carcinoma and Epstein–Barr virus infection of the stomach. Lab Invest 71:73–81
    [Google Scholar]
  5. Gradoville L., Kwa D., El-Guindy A., Miller G. 2002; Protein kinase C-independent activation of the Epstein–Barr virus lytic cycle. J Virol 76:5612–5626 [CrossRef]
    [Google Scholar]
  6. Grisham M. B., Gaginella T. S., von Ritter C., Tamai H., Be R. M., Granger D. N. 1990; Effects of neutrophil-derived oxidants on intestinal permeability, electrolyte transport, and epithelial cell viability. Inflammation 14:531–542 [CrossRef]
    [Google Scholar]
  7. Higashi H., Tsutsumi R., Muto S., Sugiyama T., Azuma T., Asaka M., Hatakeyama M. 2002; SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295:683–686 [CrossRef]
    [Google Scholar]
  8. Hoshikawa Y., Satoh Y., Murakami M., Maeta M., Kaibara N., Ito H., Kurata T., Sairenji T. 2002; Evidence of lytic infection of Epstein–Barr virus (EBV) in EBV-positive gastric carcinoma. J Med Virol 66:351–359 [CrossRef]
    [Google Scholar]
  9. Imai S., Koizumi S., Sugiura M., Tokunaga M., Uemura Y., Yamamoto N., Tanaka S., Sato E., Osato T. 1994; Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein–Barr virus latent infection protein. Proc Natl Acad Sci U S A 91:9131–9135 [CrossRef]
    [Google Scholar]
  10. Janz A., Oezel M., Kurzeder C., Mautner J., Pich D., Kost M., Hammerschmidt W., Delecluse H. J. 2000; Infectious Epstein–Barr virus lacking major glycoprotein BLLF1 (gp350/220) demonstrates the existence of additional viral ligands. J Virol 74:10142–10152 [CrossRef]
    [Google Scholar]
  11. Kieff E., Rickinson A. B. 2001; Epstein–Barr virus. In Fields Virology pp  2511–2573 Edited by Knipe D. M., Howley P. M. Philadelphia: Lippincott Williams & Wilkins;
    [Google Scholar]
  12. Kudoh A., Fujita M., Kiyono T., Kuzushima K., Sugaya Y., Izuta S., Nishiyama Y., Tsurumi T. 2003; Reactivation of lytic replication from B cells latently infected with Epstein–Barr virus occurs with high S-phase cyclin-dependent kinase activity while inhibiting cellular DNA replication. J Virol 77:851–861 [CrossRef]
    [Google Scholar]
  13. Mimuro H., Suzuki T., Tanaka J., Asahi M., Haas R., Sasakawa C. 2002; Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell 10:745–755 [CrossRef]
    [Google Scholar]
  14. Morris A., Nicholson G. 1987; Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol 82:192–199
    [Google Scholar]
  15. Murakami M., Asagoe K., Dekigai H., Kusaka S., Saita H., Kita T. 1995; Products of neutrophil metabolism increase ammonia-induced gastric mucosal damage. Dig Dis Sci 40:268–273 [CrossRef]
    [Google Scholar]
  16. Nakamura T. Y., Yamamoto I., Nishitani H., Matozaki T., Suzuki T., Wakabayashi S., Shigekawa M., Goshima K. 1995; Detachment of cultured cells from the substratum induced by the neutrophil-derived oxidant NH2Cl: synergistic role of phosphotyrosine and intracellular Ca2+ concentration. J Cell Biol 131:509–524 [CrossRef]
    [Google Scholar]
  17. Nomura A., Stemmermann G. N., Chyou P. H., Kato I., Perez-Perez G. I., Blaser M. J. 1991; Helicobacter pylor i infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 325:1132–1136 [CrossRef]
    [Google Scholar]
  18. Parsonnet J., Friedman G. D., Vandersteen D. P., Chang Y., Vogelman J. H., Orentreich N., Sibley R. K. 1991; Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:1127–1131 [CrossRef]
    [Google Scholar]
  19. Rickinson A. B., Kieff E. 2001; Epstein–Barr virus. In Fields Virology pp  2575–2627 Edited by Knipe D. M., Howley P. M. Philadelphia: Lippincott Williams & Wilkins;
    [Google Scholar]
  20. Rodriguez A., Jung E. J., Yin Q., Cayrol C., Flemington E. K. 2001; Role of c-myc regulation in Zta-mediated induction of the cyclin-dependent kinase inhibitors p21 and p27 and cell growth arrest. Virology 284:159–169 [CrossRef]
    [Google Scholar]
  21. Sato K., Watanabe S., Yoshizawa T., Hirose M., Murai T., Sato N. 1999; Ammonia, hydrogen peroxide, and monochloramine retard gastric epithelial restoration in rabbit cultured cell model. Dig Dis Sci 44:2429–2434 [CrossRef]
    [Google Scholar]
  22. Shibata D., Weiss L. M. 1992; Epstein–Barr virus-associated gastric adenocarcinoma. Am J Pathol 140:769–774
    [Google Scholar]
  23. Shinohara K., Miyazaki K., Noda N., Saitoh D., Terada M., Wakasugi H. 1998; Gastric diseases related to Helicobacter pylori and Epstein–Barr virus infection. Microbiol Immunol 42:415–421 [CrossRef]
    [Google Scholar]
  24. Sumie A., Yamashiro T., Nakashima K., Nasu M., Watanabe M., Nishizono A. 2001; Comparison of genomic structures and antigenic reactivities of orthologous 29-kilodalton outer membrane proteins of Helicobacter pylori . Infect Immun 69:6846–6852 [CrossRef]
    [Google Scholar]
  25. Suzuki M., Miura S., Suematsu M. & 7 other authors; 1992; Helicobacter pylori -associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. Am J Physiol 263:G719–G725
    [Google Scholar]
  26. Suzuki H., Mori M., Suzuki M., Sakurai K., Miura S., Ishii H. 1997; Extensive DNA damage induced by monochloramine in gastric cells. Cancer Lett 115:243–248 [CrossRef]
    [Google Scholar]
  27. Suzuki H., Seto K., Mori M., Suzuki M., Miura S., Ishii H. 1998; Monochloramine induced DNA fragmentation in gastric cell line MKN45. Am J Physiol 275:G712–G716
    [Google Scholar]
  28. Wu M. S., Shun C. T., Wu C. C., Hsu T. Y., Lin M. T., Chang M. C., Wang H. P., Lin J. T. 2000; Epstein–Barr virus-associated gastric carcinomas: relation to H. pylori infection and genetic alterations. Gastroenterology 118:1031–1038 [CrossRef]
    [Google Scholar]
  29. Yanai H., Takada K., Shimizu N., Mizugaki Y., Tada M., Okita K. 1997; Epstein–Barr virus infection in non-carcinomatous gastric epithelium. J Pathol 183:293–298 [CrossRef]
    [Google Scholar]
  30. Yoshiyama H., Imai S., Shimizu N., Takada K. 1997; Epstein–Barr virus infection of human gastric carcinoma cells: implication of the existence of a new virus receptor different from CD21. J Virol 71:5688–5691
    [Google Scholar]
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