@article{mbs:/content/journal/jmm/10.1099/jmm.0.46441-0, author = "Seol, Sung Yong and Kim, Yong Tae and Jeong, Young Sook and Oh, Jae Young and Kang, Hee Young and Moon, Dong Chan and Kim, Jungmin and Lee, Yoo Chul and Cho, Dong Taek and Lee, Je Chul", title = "Molecular characterization of antimicrobial resistance in Shigella sonnei isolates in Korea", journal= "Journal of Medical Microbiology", year = "2006", volume = "55", number = "7", pages = "871-877", doi = "https://doi.org/10.1099/jmm.0.46441-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.46441-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "R plasmid, resistance plasmid", keywords = "ESBL, extended-spectrum β-lactamase", abstract = "The antimicrobial resistance of 122 Shigella sonnei isolates obtained in Korea during the period 1991–2000 was characterized. These isolates were highly resistant to traditional antibiotics such as trimethoprim (100 %), streptomycin (100 %), sulfamethoxazole (94 %), tetracycline (93 %) and nalidixic acid (90 %). All S. sonnei isolates carried Tn7 in their chromosomes. The 8.4 kb non-transferable resistance (R) plasmid carrying tetA, strA-strB and sul1 was found in 93 % of the S. sonnei isolates. Resistance to nalidixic acid first appeared in a S. sonnei isolate in 1997, and then in all S. sonnei isolates from 1998 and 1999. Resistance to commonly prescribed antibiotics such as ampicillin was increased in S. sonnei isolates during the outbreak period 1998–2000. Resistance to ampicillin was mediated by the conjugative R plasmids carrying bla TEM-1. In conclusion, S. sonnei acquired antimicrobial resistance to commonly prescribed antibiotics through the horizontal transfer of conjugative R plasmids, while the genetic stability of transposon and non-transferable R plasmids was responsible for resistance to traditional antibiotics.", }