1887

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Volume 55, Issue 7

infection of microglial cells : a model of microbial infection for neurological disease Free

Abstract

is the aetiological cause of a wide variety of chronic inflammatory diseases and may be associated with neurological disease. Microbiological and immunological aspects of the interaction between and the central nervous system (CNS) are not well understood because of the lack of a suitable infection model for neuronal studies. In the present study, an infection model was developed in the established microglial cell line EOC 20. Infection of the cells resulted in obvious induction of proinflammatory cytokines. The infection also selectively induced matrix metalloproteinase-9 (MMP-9) but not MMP-2. Moreover, beta interferon, which is known to modulate CNS disease, inhibited induction of MMP-9 following infection. These results support the view that infection may be associated with marked alteration of the ability of microglial cells to enhance cytokine production as well as induction of an MMP.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): CNS, central nervous system , IFN-β, beta interferon , IFU, inclusion-forming units , IL-10, interleukin-10 , IL-12, interleukin-12 , MMP-9, matrix metalloproteinase-9 , MS, multiple sclerosis , TIMP-1, tissue inhibitor of metalloprotease 1 and TNF-α, tumour necrosis factor α
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2006-07-01
2024-04-19
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Chlamydia pneumoniae infection of microglial cells in vitro: a model of microbial infection for neurological disease
J. Med. Microbiol. 55, 947 (2006); https://doi.org/10.1099/jmm.0.46348-0
/content/journal/jmm/10.1099/jmm.0.46348-0
/content/journal/jmm/10.1099/jmm.0.46348-0
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