1887

Abstract

Chronic heart failure (CHF) involves interactions between the cardiovascular, neuroendocrine and immune systems. This study investigated the seropositivity rate for anti- IgG and IgM antibodies by ELISA in patients with CHF. Ninety-seven patients with CHF and 50 healthy volunteers were selected for this investigation. The seropositivity rate for anti- IgG antibodies among CHF patients (68 %) was significantly higher than in healthy volunteers (36 %). Thus, parasitological screening of this group of patients should be periodically performed to prevent the possible dissemination of toxoplasmosis.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.46255-0
2006-01-01
2019-11-21
Loading full text...

Full text loading...

/deliver/fulltext/jmm/55/1/89.html?itemId=/content/journal/jmm/10.1099/jmm.0.46255-0&mimeType=html&fmt=ahah

References

  1. Altintas, N., Yolasigmaz, A., Yazar, S., Sakru, N. & Kitapcioglu, G. ( 1998; ). Investigation of Toxoplasma antibodies in residence of central Izmir and surrounding rural area. Act Parasitol Tur 22, 229–232.
    [Google Scholar]
  2. Baumgarten, G., Knuefermann, P. & Mann, D. L. ( 2000; ). Cytokines as emerging targets in the treatment of heart failure. Trends Cardiovasc Med 10, 216–223.[CrossRef]
    [Google Scholar]
  3. Beaver, P. C., Jung, R. C. & Cupp, E. W. ( 1984; ). Clinical Parasitology, 9th edn. Philadelphia: Lea & Febiger.
  4. Campbell, K. S. & Colonna, M. ( 2001; ). Human natural killer cell receptors and signal transduction. Int Rev Immunol 20, 333–370.[CrossRef]
    [Google Scholar]
  5. Daffos, F., Forestier, F., Capella-Pavlovsky, M., Thulliez, P., Aufrant, C., Valenti, D. & Cox, W. L. ( 1988; ). Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis. N Engl J Med 318, 271–275.[CrossRef]
    [Google Scholar]
  6. Denkers, E. Y. & Gazzinelli, R. T. ( 1998; ). Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 11, 569–588.
    [Google Scholar]
  7. Deswal, A., Petersen, N. J., Feldman, A. M., Young, J. B., White, B. G. & Mann, D. L. ( 2001; ). Cytokines and cytokine receptors in advanced heart failure. An analysis of the cytokine database from the vesnarinone trial (VEST). Circulation 103, 2055–2059.[CrossRef]
    [Google Scholar]
  8. Dubey, J. P. & Beattie, C. P. ( 1988; ). Toxoplasmosis of Animals and Man. Boca Raton, FL: CRC Press.
  9. Feldman, H. ( 1982; ). Epidemiology of Toxoplasma infections. Epidemiol Rev 4, 204–213.
    [Google Scholar]
  10. Ferreira, M. S. & Borges, A. S. ( 2002; ). Some aspects of protozoan infections in immunocompromised patients: a review. Mem Inst Oswaldo Cruz 97, 443–457.[CrossRef]
    [Google Scholar]
  11. Fuccillo, E. A., Madden, E. E., Tzan, N. & Sever, J. L. ( 1987; ). Difficulties associated with serological diagnosis of Toxoplasma gondii infections. Diagn Clin Immunol 5, 8–13.
    [Google Scholar]
  12. Garcia, S. L. & Bruckner, A. D. ( 1997a; ). Tissue protozoa (Toxoplasma gondii). In Diagnostic Medical Parasitology, pp. 111–121. Edited by S. L. Garcia & A. D. Bruckner. Washington, DC: American Society for Microbiology.
  13. Garcia, S. L. & Bruckner, A. D. ( 1997b; ). Parasitic infections in the compromised host (Toxoplasma gondii). In Diagnostic Medical Parasitology, pp. 423–424. Edited by S. L. Garcia & A. D. Bruckner. Washington, DC: American Society for Microbiology.
  14. Gazzinelli, R. T., Wysocka, M., Hayashi, S., Denkers, E. Y., Hieny, S., Caspar, P., Trinchieri, G. & Sher, A. ( 1994; ). Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 153, 2533–2543.
    [Google Scholar]
  15. Kagi, D., Ledermann, B., Burki, K., Zinkernagel, R. M. & Hengartner, H. ( 1996; ). Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 14, 207–232.[CrossRef]
    [Google Scholar]
  16. Kos, F. J. ( 1998; ). Regulation of adaptive immunity by natural killer cells. Immunol Res 17, 303–312.[CrossRef]
    [Google Scholar]
  17. Luft, B. J. & Remington, J. S. ( 1988; ). Toxoplasmosis encephalitis. J Infect Dis 157, 1–6.[CrossRef]
    [Google Scholar]
  18. Montoya, J. G. & Remington, J. S. ( 2000; ). Toxoplasma gondii. In Principles and Practice of Infectious Diseases, pp. 2858–2888. Edited by G. L. Mandell, J. E. Bennett & R. Dolin. Philadelphia: Churchill Livingstone.
  19. Mordue, D. G., Monroy, F., La Regina, M., Dinarello, C. A. & Sibley, L. D. ( 2001; ). Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines. J Immunol 167, 4574–4584.[CrossRef]
    [Google Scholar]
  20. Moretta, L., Bottina, C., Pende, D., Mingari, M. C., Biassoni, R. & Moretta, A. ( 2002; ). Human natural killer cells: their origin, receptors and function. Eur J Immunol 32, 1205–1211.[CrossRef]
    [Google Scholar]
  21. Navia, B. A., Petito, C. K., Gold, J. W. M., Cho, E. S., Jordon, B. D. & Price, J. W. ( 1986; ). Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients. Ann Neurol 19, 224–238.[CrossRef]
    [Google Scholar]
  22. Neyer, L. E., Grunig, G., Fort, M., Remington, J. S., Rennick, D. & Hunter, C. A. ( 1997; ). Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii. Infect Immun 65, 1675–1682.
    [Google Scholar]
  23. Satoskar, A. R., Stamm, L. M., Zhang, X., Okano, M., David, J. R., Terhorst, C. & Wang, B. ( 1999; ). NK cell-deficient mice develop a Th1-like response but fail to mount an efficient antigen-specific IgG2a antibody response. J Immunol 163, 5298–5302.
    [Google Scholar]
  24. Scharton-Kersten, T. M., Wynn, T. A., Denkers, E. Y., Bala, S., Showe, L., Grunvald, E., Hieny, S., Gazzinelli, R. T. & Sher, A. ( 1996; ). In the absence of endogenous IFN-γ mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol 157, 4045–4054.
    [Google Scholar]
  25. Vredevoe, D. L., Moser, D. K., Gan, X. H. & Bonavida, B. ( 1995; ). Natural killer cell anergy to cytokine stimulants in a subgroup of patients with heart failure: relationship to norepinephrine. Neuroimmunomodulation 2, 16–24.[CrossRef]
    [Google Scholar]
  26. Yazar, S., Karagoz, S., Altunoluk, B. & Kilic, H. ( 2000; ). Investigation of anti-Toxoplasma gondii antibodies in patients suspected of toxoplasmosis. Act Parasitol Tur 24, 14–16.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.46255-0
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error