1887

Abstract

The host range of well-characterized mycobacteriophages, such as D29 and TM4, has been determined, together with that of more recently isolated mycobacteriophages, in , , BCG, , , , and . Here, a set of virulent phages for , a pathogen with a dramatic increase of incidence over the last decade, is demonstrated. In this work, a mycobacteriophage replication assay was adapted for the identification and rifampicin-susceptibility testing of . Mycobacteriophages have generated a number of useful tools and enabled insights into mycobacterial genetics. With regard to the neglected pathogen , the findings presented in this work allow the application of a large range of phage-based vectors and markers. The potential of phage therapy can now be evaluated for this extracellular pathogen.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.46238-0
2006-01-01
2019-10-17
Loading full text...

Full text loading...

/deliver/fulltext/jmm/55/1/37.html?itemId=/content/journal/jmm/10.1099/jmm.0.46238-0&mimeType=html&fmt=ahah

References

  1. Albert, H., Muzaffar, R., Mole, R. J. & Trollip, A. P. ( 2002; ). Use of the FASTPlaque test for TB diagnosis in low-income countries. Int J Tuberc Lung Dis 6, 1130–1131 (author reply 1131–1132).
    [Google Scholar]
  2. Alcaide, F., Gali, N., Dominguez, J., Berlanga, P., Blanco, S., Orus, P. & Martin, R. ( 2003; ). Usefulness of a new mycobacteriophage-based technique for rapid diagnosis of pulmonary tuberculosis. J Clin Microbiol 41, 2867–2871.[CrossRef]
    [Google Scholar]
  3. Banaiee, N., Bobadilla-del-Valle, M., Riska, P. F., Bardarov, S., Jr, Small, P. M., Ponce-de-Leon, A., Jacobs, W. R., Jr, Hatfull, G. F. & Sifuentes-Osornio, J. ( 2003; ). Rapid identification and susceptibility testing of Mycobacterium tuberculosis from MGIT cultures with luciferase reporter mycobacteriophages. J Med Microbiol 52, 557–561.[CrossRef]
    [Google Scholar]
  4. Bardarov, S., Kriakov, J., Carriere, C., Yu, S., Vaamonde, C., McAdam, R. A., Bloom, B. R., Hatfull, G. F. & Jacobs, W. R., Jr ( 1997; ). Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 94, 10961–10966.[CrossRef]
    [Google Scholar]
  5. Broxmeyer, L., Sosnowska, D., Miltner, E., Chacon, O., Wagner, D., McGarvey, J., Barletta, R. G. & Bermudez, L. E. ( 2002; ). Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens. J Infect Dis 186, 1155–1160.[CrossRef]
    [Google Scholar]
  6. Butt, T., Ahmad, R. N., Afzal, R. K., Mahmood, A. & Anwar, M. ( 2004; ). Rapid detection of rifampicin susceptibility of Mycobacterium tuberculosis in sputum specimens by mycobacteriophage assay. J Pak Med Assoc 54, 379–382.
    [Google Scholar]
  7. Crawford, J. & Bates, J. H. ( 1984; ). Phage typing of mycobacteria. In The Biology of Mycobacteria: a Sourcebook, pp. 309–351. Edited by G. P. Kubica & L. G. Wayne. London: Academic Press.
  8. Doke, S. ( 1960; ). Studies on mycobacteriohages and lysogenic mycobacteria. J Kumamoto Med Soc 34, 1360–1373.
    [Google Scholar]
  9. Espey, D. K., Meyers, W. M., Portaels, F. & 9 other authors ( 2002; ). A pilot study of treatment of Buruli ulcer with rifampin and dapsone. Int J Infect Dis 6, 60–65.[CrossRef]
    [Google Scholar]
  10. Foley-Thomas, E. M., Whipple, D. L., Bermudez, L. E. & Barletta, R. G. ( 1995; ). Phage infection, transfection and transformation of Mycobacterium avium complex and Mycobacterium paratuberculosis. Microbiology 141, 1173–1181.[CrossRef]
    [Google Scholar]
  11. Ford, M. E., Sarkis, G. J., Belanger, A. E., Hendrix, R. W. & Hatfull, G. F. ( 1998; ). Genome structure of mycobacteriophage D29: implications for phage evolution. J Mol Biol 279, 143–164.[CrossRef]
    [Google Scholar]
  12. Froman, S., Will, D. W. & Bogen, E. ( 1954; ). Bacteriophage active against virulent Mycobacterium tuberculosis. I. Isolation and activity. Am J Public Health 44, 1326–1333.[CrossRef]
    [Google Scholar]
  13. George, K. M., Chatterjee, D., Gunawardana, G., Welty, D., Hayman, J., Lee, R. & Small, P. L. ( 1999; ). Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. Science 283, 854–857.[CrossRef]
    [Google Scholar]
  14. Harris, N. B., Feng, Z., Liu, X., Cirillo, S. L., Cirillo, J. D. & Barletta, R. G. ( 1999; ). Development of a transposon mutagenesis system for Mycobacterium avium subsp. paratuberculosis. FEMS Microbiol Lett 175, 21–26.[CrossRef]
    [Google Scholar]
  15. Hatfull, G. F. & Sarkis, G. J. ( 1993; ). DNA sequence, structure and gene expression of mycobacteriophage L5: a phage system for mycobacterial genetics. Mol Microbiol 7, 395–405.[CrossRef]
    [Google Scholar]
  16. Jacobs, W. R., Jr, Barletta, R. G., Udani, R. & 7 other authors ( 1993; ). Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages. Science 260, 819–822.[CrossRef]
    [Google Scholar]
  17. Marsollier, L., Honore, N., Legras, P., Manceau, A. L., Kouakou, H., Carbonnelle, B. & Cole, S. T. ( 2003; ). Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice. Antimicrob Agents Chemother 47, 1228–1232.[CrossRef]
    [Google Scholar]
  18. McNerney, R., Wilson, S. M., Sidhu, A. M., Harley, V. S., al Suwaidi, Z., Nye, P. M., Parish, T. & Stoker, N. G. ( 1998; ). Inactivation of mycobacteriophage D29 using ferrous ammonium sulphate as a tool for the detection of viable Mycobacterium smegmatis and M. tuberculosis. Res Microbiol 149, 487–495.[CrossRef]
    [Google Scholar]
  19. McNerney, R., Kambashi, B. S., Kinkese, J., Tembwe, R. & Godfrey-Faussett, P. ( 2004; ). Development of a bacteriophage phage replication assay for diagnosis of pulmonary tuberculosis. J Clin Microbiol 42, 2115–2120.[CrossRef]
    [Google Scholar]
  20. Muzaffar, R., Batool, S., Aziz, F., Naqvi, A. & Rizvi, A. ( 2002; ). Evaluation of the FASTPlaqueTB assay for direct detection of Mycobacterium tuberculosis in sputum specimens. Int J Tuberc Lung Dis 6, 635–640.
    [Google Scholar]
  21. Mve-Obiang, A., Lee, R. E., Portaels, F. & Small, P. L. ( 2003; ). Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence. Infect Immun 71, 774–783.[CrossRef]
    [Google Scholar]
  22. Pearson, R. E., Jurgensen, S., Sarkis, G. J., Hatfull, G. F. & Jacobs, W. R., Jr ( 1996; ). Construction of D29 shuttle phasmids and luciferase reporter phages for detection of mycobacteria. Gene 183, 129–136.[CrossRef]
    [Google Scholar]
  23. Pedulla, M. L., Ford, M. E., Houtz, J. M. & 17 other authors ( 2003; ). Origins of highly mosaic mycobacteriophage genomes. Cell 113, 171–182.[CrossRef]
    [Google Scholar]
  24. Portaels, F., Fonteyene, P. A., de Beenhouwer, H., de Rijk, P., Guedenon, A., Hayman, J. & Meyers, M. W. ( 1996; ). Variability in 3′ end of 16S rRNA sequence of Mycobacterium ulcerans is related to geographic origin of isolates. J Clin Microbiol 34, 962–965.
    [Google Scholar]
  25. Rybniker, J., Wolke, M., Haefs, C. & Plum, G. ( 2003; ). Transposition of Tn5367 in Mycobacterium marinum, using a conditionally recombinant mycobacteriophage. J Bacteriol 185, 1745–1748.[CrossRef]
    [Google Scholar]
  26. Sarkis, J. S. & Hatfull, G. F. ( 1998; ). Mycobacteriophages. In Mycobacteria Protocols, pp. 145–173. Edited by T. Parish & N. G. Stoker. Totowa, NJ: Humana Press.
  27. Simboli, N., Takiff, H., McNerney, R., Lopez, B., Martin, A., Palomino, J. C., Barrera, L. & Ritacco, V. ( 2005; ). In-house phage amplification assay is a sound alternative for detecting rifampin-resistant Mycobacterium tuberculosis in low-resource settings. Antimicrob Agents Chemother 49, 425–427.[CrossRef]
    [Google Scholar]
  28. Snapper, S. B., Melton, R. E., Mustafa, S., Kieser, T. & Jacobs, W. R., Jr ( 1990; ). Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol Microbiol 4, 1911–1919.[CrossRef]
    [Google Scholar]
  29. Stinear, T. P., Mve-Obiang, A., Small, P. L. & 12 other authors ( 2004; ). Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc Natl Acad Sci U S A 101, 1345–1349.[CrossRef]
    [Google Scholar]
  30. Thangaraj, H. S., Phillips, R. O., Evans, M. R. & Wansbrough-Jones, M. H. ( 2003; ). Emerging aspects of Buruli ulcer. Expert Rev Anti Infect Ther 1, 217–222.[CrossRef]
    [Google Scholar]
  31. Timme, T. L. & Brennan, P. J. ( 1984; ). Induction of bacteriophage from members of the Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium scrofulaceum serocomplex. J Gen Microbiol 130, 2059–2066.
    [Google Scholar]
  32. Weir, E. ( 2002; ). Buruli ulcer: the third most common mycobacterial infection. Can Med Assoc J 166, 1691.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.46238-0
Loading
/content/journal/jmm/10.1099/jmm.0.46238-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error