1887

Abstract

The host range of well-characterized mycobacteriophages, such as D29 and TM4, has been determined, together with that of more recently isolated mycobacteriophages, in , , BCG, , , , and . Here, a set of virulent phages for , a pathogen with a dramatic increase of incidence over the last decade, is demonstrated. In this work, a mycobacteriophage replication assay was adapted for the identification and rifampicin-susceptibility testing of . Mycobacteriophages have generated a number of useful tools and enabled insights into mycobacterial genetics. With regard to the neglected pathogen , the findings presented in this work allow the application of a large range of phage-based vectors and markers. The potential of phage therapy can now be evaluated for this extracellular pathogen.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.46238-0
2006-01-01
2020-07-02
Loading full text...

Full text loading...

/deliver/fulltext/jmm/55/1/37.html?itemId=/content/journal/jmm/10.1099/jmm.0.46238-0&mimeType=html&fmt=ahah

References

  1. Albert H., Muzaffar R., Mole R. J., Trollip A. P. 2002; Use of the FASTPlaque test for TB diagnosis in low-income countries. Int J Tuberc Lung Dis 6:1130–1131 (author reply 1131–1132
    [Google Scholar]
  2. Alcaide F., Gali N., Dominguez J., Berlanga P., Blanco S., Orus P., Martin R. 2003; Usefulness of a new mycobacteriophage-based technique for rapid diagnosis of pulmonary tuberculosis. J Clin Microbiol 41:2867–2871 [CrossRef]
    [Google Scholar]
  3. Banaiee N., Bobadilla-del-Valle M., Riska P. F., Bardarov S. Jr, Small P. M., Ponce-de-Leon A., Jacobs W. R. Jr, Hatfull G. F., Sifuentes-Osornio J. 2003; Rapid identification and susceptibility testing of Mycobacterium tuberculosis from MGIT cultures with luciferase reporter mycobacteriophages. J Med Microbiol 52:557–561 [CrossRef]
    [Google Scholar]
  4. Bardarov S., Kriakov J., Carriere C., Yu S., Vaamonde C., McAdam R. A., Bloom B. R., Hatfull G. F., Jacobs W. R. Jr 1997; Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis . Proc Natl Acad Sci U S A 94:10961–10966 [CrossRef]
    [Google Scholar]
  5. Broxmeyer L., Sosnowska D., Miltner E., Chacon O., Wagner D., McGarvey J., Barletta R. G., Bermudez L. E. 2002; Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens. J Infect Dis 186:1155–1160 [CrossRef]
    [Google Scholar]
  6. Butt T., Ahmad R. N., Afzal R. K., Mahmood A., Anwar M. 2004; Rapid detection of rifampicin susceptibility of Mycobacterium tuberculosis in sputum specimens by mycobacteriophage assay. J Pak Med Assoc 54:379–382
    [Google Scholar]
  7. Crawford J., Bates J. H. 1984; Phage typing of mycobacteria. In The Biology of Mycobacteria: a Sourcebook pp  309–351 Edited by Kubica G. P., Wayne L. G. London: Academic Press;
    [Google Scholar]
  8. Doke S. 1960; Studies on mycobacteriohages and lysogenic mycobacteria. J Kumamoto Med Soc 34:1360–1373
    [Google Scholar]
  9. Espey D. K., Meyers W. M., Portaels F. & 9 other authors; 2002; A pilot study of treatment of Buruli ulcer with rifampin and dapsone. Int J Infect Dis 6:60–65 [CrossRef]
    [Google Scholar]
  10. Foley-Thomas E. M., Whipple D. L., Bermudez L. E., Barletta R. G. 1995; Phage infection, transfection and transformation of Mycobacterium avium complex and Mycobacterium paratuberculosis . Microbiology 141:1173–1181 [CrossRef]
    [Google Scholar]
  11. Ford M. E., Sarkis G. J., Belanger A. E., Hendrix R. W., Hatfull G. F. 1998; Genome structure of mycobacteriophage D29: implications for phage evolution. J Mol Biol 279:143–164 [CrossRef]
    [Google Scholar]
  12. Froman S., Will D. W., Bogen E. 1954; Bacteriophage active against virulent Mycobacterium tuberculosis . I. Isolation and activity. Am J Public Health 44:1326–1333 [CrossRef]
    [Google Scholar]
  13. George K. M., Chatterjee D., Gunawardana G., Welty D., Hayman J., Lee R., Small P. L. 1999; Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. Science 283:854–857 [CrossRef]
    [Google Scholar]
  14. Harris N. B., Feng Z., Liu X., Cirillo S. L., Cirillo J. D., Barletta R. G. 1999; Development of a transposon mutagenesis system for Mycobacterium avium subsp. paratuberculosis . FEMS Microbiol Lett 175:21–26 [CrossRef]
    [Google Scholar]
  15. Hatfull G. F., Sarkis G. J. 1993; DNA sequence, structure and gene expression of mycobacteriophage L5: a phage system for mycobacterial genetics. Mol Microbiol 7:395–405 [CrossRef]
    [Google Scholar]
  16. Jacobs W. R. Jr, Barletta R. G., Udani R. & 7 other authors; 1993; Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages. Science 260:819–822 [CrossRef]
    [Google Scholar]
  17. Marsollier L., Honore N., Legras P., Manceau A. L., Kouakou H., Carbonnelle B., Cole S. T. 2003; Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice. Antimicrob Agents Chemother 47:1228–1232 [CrossRef]
    [Google Scholar]
  18. McNerney R., Wilson S. M., Sidhu A. M., Harley V. S., al Suwaidi Z., Nye P. M., Parish T., Stoker N. G. 1998; Inactivation of mycobacteriophage D29 using ferrous ammonium sulphate as a tool for the detection of viable Mycobacterium smegmatis and M. tuberculosis . Res Microbiol 149:487–495 [CrossRef]
    [Google Scholar]
  19. McNerney R., Kambashi B. S., Kinkese J., Tembwe R., Godfrey-Faussett P. 2004; Development of a bacteriophage phage replication assay for diagnosis of pulmonary tuberculosis. J Clin Microbiol 42:2115–2120 [CrossRef]
    [Google Scholar]
  20. Muzaffar R., Batool S., Aziz F., Naqvi A., Rizvi A. 2002; Evaluation of the FASTPlaqueTB assay for direct detection of Mycobacterium tuberculosis in sputum specimens. Int J Tuberc Lung Dis 6:635–640
    [Google Scholar]
  21. Mve-Obiang A., Lee R. E., Portaels F., Small P. L. 2003; Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans : implications for virulence. Infect Immun 71:774–783 [CrossRef]
    [Google Scholar]
  22. Pearson R. E., Jurgensen S., Sarkis G. J., Hatfull G. F., Jacobs W. R. Jr 1996; Construction of D29 shuttle phasmids and luciferase reporter phages for detection of mycobacteria. Gene 183:129–136 [CrossRef]
    [Google Scholar]
  23. Pedulla M. L., Ford M. E., Houtz J. M. & 17 other authors; 2003; Origins of highly mosaic mycobacteriophage genomes. Cell 113:171–182 [CrossRef]
    [Google Scholar]
  24. Portaels F., Fonteyene P. A., de Beenhouwer H., de Rijk P., Guedenon A., Hayman J., Meyers M. W. 1996; Variability in 3′ end of 16S rRNA sequence of Mycobacterium ulcerans is related to geographic origin of isolates. J Clin Microbiol 34:962–965
    [Google Scholar]
  25. Rybniker J., Wolke M., Haefs C., Plum G. 2003; Transposition of Tn 5367 in Mycobacterium marinum , using a conditionally recombinant mycobacteriophage. J Bacteriol 185:1745–1748 [CrossRef]
    [Google Scholar]
  26. Sarkis J. S., Hatfull G. F. 1998; Mycobacteriophages. In Mycobacteria Protocols pp  145–173 Edited by Parish T., Stoker N. G. Totowa, NJ: Humana Press;
    [Google Scholar]
  27. Simboli N., Takiff H., McNerney R., Lopez B., Martin A., Palomino J. C., Barrera L., Ritacco V. 2005; In-house phage amplification assay is a sound alternative for detecting rifampin-resistant Mycobacterium tuberculosis in low-resource settings. Antimicrob Agents Chemother 49:425–427 [CrossRef]
    [Google Scholar]
  28. Snapper S. B., Melton R. E., Mustafa S., Kieser T., Jacobs W. R. Jr 1990; Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis . Mol Microbiol 4:1911–1919 [CrossRef]
    [Google Scholar]
  29. Stinear T. P., Mve-Obiang A., Small P. L. & 12 other authors; 2004; Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans . Proc Natl Acad Sci U S A 101:1345–1349 [CrossRef]
    [Google Scholar]
  30. Thangaraj H. S., Phillips R. O., Evans M. R., Wansbrough-Jones M. H. 2003; Emerging aspects of Buruli ulcer. Expert Rev Anti Infect Ther 1:217–222 [CrossRef]
    [Google Scholar]
  31. Timme T. L., Brennan P. J. 1984; Induction of bacteriophage from members of the Mycobacterium avium , Mycobacterium intracellulare , Mycobacterium scrofulaceum serocomplex. J Gen Microbiol 130:2059–2066
    [Google Scholar]
  32. Weir E. 2002; Buruli ulcer: the third most common mycobacterial infection. Can Med Assoc J 166:1691
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.46238-0
Loading
/content/journal/jmm/10.1099/jmm.0.46238-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error