Fatal pulmonary infection in a leukaemic patient caused by Free

Abstract

A case of autopsy-proven fungal pneumonia in a relapsed leukaemia patient is reported. The fungus was cultured from two bronchoalveolar fluid samples and identified through morphological examination and ITS2 sequence analysis. In addition, galactomannan was detected in eight consecutive serum samples, which suggested a co-infection with species. The patient was treated with caspofungin.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.46016-0
2005-07-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/54/7/JM540711.html?itemId=/content/journal/jmm/10.1099/jmm.0.46016-0&mimeType=html&fmt=ahah

References

  1. Adam O., Auperin A., Wilquin F., Bourhis J. H., Gachot B., Chachaty E. 2004; Treatment with piperacillin-tazobactam and false-positive Aspergillus galactomannan antigen test results for patients with hematological malignancies. Clin Infect Dis 38:917–920 [CrossRef]
    [Google Scholar]
  2. Ascioglu S., Rex J. H., de Pauw B. & 17 other authors; 2002; Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34:7–14 [CrossRef]
    [Google Scholar]
  3. Bartz-Schmidt K. U., Tintelnot K., Steffen M., Ozel M., Kirchhof B., Heimann K. 1996; Chronic basidiomycetous endophthalmitis after extracapsular cataract extraction and intraocular lens implantation. Graefe's Arch Clin Exp Ophthalmol 234:591–593 [CrossRef]
    [Google Scholar]
  4. De Baere T., Claeys G., Swinne D., Verschraegen G., Muylaert A., Massonet C., Vaneechoutte M. 2002; Identification of cultured isolates of clinically important yeast species using fluorescent fragment length analysis of the amplified internally transcribed rRNA spacer 2 region (ITS2). BMC Microbiol 2:21– 21 [CrossRef]
    [Google Scholar]
  5. de Hoog G. S., Gerrits van den Ende A. H. 1998; Molecular diagnostics of clinical strains of filamentous Basidiomycetes. Mycoses 41:183–189 [CrossRef]
    [Google Scholar]
  6. Gene J., Guillamon J. M., Guarro J., Pujol I., Ulfig K. 1996; Molecular characterization, relatedness and antifungal susceptibility of the basidiomycetous Hormographiella species and Coprinus cinereus from clinical and environmental sources. Antonie Van Leeuwenhoek 70:49–57 [CrossRef]
    [Google Scholar]
  7. Guarro J., Gene J., de Vroey C., Guého E. 1992; Hormographiella , a new genus of hyphomycetes from clinical sources. Mycotaxon 45:179–190
    [Google Scholar]
  8. Nenoff P., Friedrich T., Schwenke H., Mierzwa M., Horn L. C., Haustein U. F. 1997; Rare fatal simultaneous mould infection of the lung caused by Aspergillus flavus and the basidiomycete Coprinus sp.in a leukemic patient. J Med Vet Mycol 35:65–69 [CrossRef]
    [Google Scholar]
  9. Pfaller M. A., Messer S. A., Mills K., Bolmstrom A. 2000; In vitro susceptibility testing of filamentous fungi: comparison of Etest and reference microdilution methods for determining itraconazole MICs. J Clin Microbiol 38:3359–3361
    [Google Scholar]
  10. Speller D. E., MacIver A. G. 1971; Endocarditis caused by a Coprinus species: a fungus of the toadstool group. J Med Microbiol 4:370–374 [CrossRef]
    [Google Scholar]
  11. Surmont I., van Aelst F., Verbanck J., de Hoog G. S. 2002; A pulmonary infection caused by Coprinus cinereus ( Hormographiella aspergillata ) diagnosed after a neutropenic episode. Med Mycol 40:217–219 [CrossRef]
    [Google Scholar]
  12. Verweij P. E., van Kasteren M., van de Nes J., de Hoog G. S., de Pauw B. E., Meis J. F. 1997; Fatal pulmonary infection caused by the basidiomycete Hormographiella aspergillata . J Clin Microbiol 35:2675–2678
    [Google Scholar]
  13. Wheat L. J. 2003; Rapid diagnosis of invasive aspergillosis by antigen detection. Transpl Infect Dis 5:158–166 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.46016-0
Loading
/content/journal/jmm/10.1099/jmm.0.46016-0
Loading

Data & Media loading...

Most cited Most Cited RSS feed