A case of autopsy-proven fungal pneumonia in a relapsed leukaemia patient is reported. The fungus Hormographiella aspergillata was cultured from two bronchoalveolar fluid samples and identified through morphological examination and ITS2 sequence analysis. In addition, galactomannan was detected in eight consecutive serum samples, which suggested a co-infection with Aspergillus species. The patient was treated with caspofungin.
AsciogluS.,
RexJ. H.,
de PauwB. & 17 other authors; 2002; Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34:7–14[CrossRef]
De BaereT.,
ClaeysG.,
SwinneD.,
VerschraegenG.,
MuylaertA.,
MassonetC.,
VaneechoutteM.2002; Identification of cultured isolates of clinically important yeast species using fluorescent fragment length analysis of the amplified internally transcribed rRNA spacer 2 region (ITS2). BMC Microbiol 2:21– 21[CrossRef]
GeneJ.,
GuillamonJ. M.,
GuarroJ.,
PujolI.,
UlfigK.1996; Molecular characterization, relatedness and antifungal susceptibility of the basidiomycetous Hormographiella species and Coprinus cinereus from clinical and environmental sources. Antonie Van Leeuwenhoek 70:49–57[CrossRef]
NenoffP.,
FriedrichT.,
SchwenkeH.,
MierzwaM.,
HornL. C.,
HausteinU. F.1997; Rare fatal simultaneous mould infection of the lung caused by Aspergillus flavus and the basidiomycete Coprinus sp.in a leukemic patient. J Med Vet Mycol 35:65–69[CrossRef]
PfallerM. A.,
MesserS. A.,
MillsK.,
BolmstromA.2000; In vitro susceptibility testing of filamentous fungi: comparison of Etest and reference microdilution methods for determining itraconazole MICs. J Clin Microbiol 38:3359–3361
SurmontI.,
van AelstF.,
VerbanckJ.,
de HoogG. S.2002; A pulmonary infection caused by Coprinus cinereus ( Hormographiella aspergillata ) diagnosed after a neutropenic episode. Med Mycol 40:217–219[CrossRef]
VerweijP. E.,
van KasterenM.,
van de NesJ.,
de HoogG. S.,
de PauwB. E.,
MeisJ. F.1997; Fatal pulmonary infection caused by the basidiomycete Hormographiella aspergillata
. J Clin Microbiol 35:2675–2678