1887

Abstract

A novel compound 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate was isolated from the plant L. The activity of this dihydropyrrole derivative against and species was evaluated by using standard methods approved by the National Committee for Clinical Laboratory Standards. The compound was found to be active against all the species tested, namely , , , and . The MIC at which more than 90 % of growth was inhibited (MIC) by the compound ranged from 21.87 to 43.75 μg ml against various fungal species by microbroth dilution assay. Since the compound 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate has antifungal activity it can be explored further to develop new antimycotic drugs.

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2005-06-01
2019-11-17
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References

  1. Bartizal, K., Gill, C. J., Abruzzo, G. K. & 8 other authors ( 1997;). In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872). Antimicrob Agents Chemother 41, 2326–2332.
    [Google Scholar]
  2. Dabur, R., Ali, M., Singh, H., Gupta, J. & Sharma, G. L. ( 2004;). A novel antifungal pyrrole derivative from Datura metel leaves. Die Pharmazie 59, 568–570.
    [Google Scholar]
  3. Denning, D. W. & Stevens, D. A. ( 1990;). Antifungal and surgical treatment of invasive aspergillosis review of 2121 published cases. Rev Infect Dis 12, 1147–1201.[CrossRef]
    [Google Scholar]
  4. Kurtz, M. B., Heath, I. B., Marrinan, J., Dreikorn, S., Onishi, J. & Douglas, C. ( 1994;). Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-d-glucan synthase. Antimicrob Agents Chemother 38, 1480–1489.[CrossRef]
    [Google Scholar]
  5. Meyer, J. D. ( 1990;). Fungal infection in bone marrow transplants patients. Semin Oncol 17, 10–13.
    [Google Scholar]
  6. NCCLS ( 1997). Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard, document M27-A. Wayne, PA; National Committee for Clinical Laboratory Standards.
  7. Pfaller, M. A. ( 1994;). Epidemiology and control of fungal infections. Clin Infect Dis 19 Suppl 1, S8–S13.
    [Google Scholar]
  8. Pfaller, M. A., Jones, R. N., Messer, S. A., Edmond, M. B. & Wenzel, R. P. ( 1998a;). National surveillance of nosocomial blood stream isolates due to Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE program. Diagn Microbiol Infect Dis 31, 327–332.[CrossRef]
    [Google Scholar]
  9. Pfaller, M. A., Marco, F., Messer, S. A. & Jones, R. N. ( 1998b;). In vitro activity of two echinocandin derivatives, LY303366 and MK-0991 (L-743,792), against clinical isolates of Aspergillus, Fusarium, Rhizopus, and other filamentous fungi. Diagn Microbiol Infect Dis 30, 251–255.[CrossRef]
    [Google Scholar]
  10. Pfaller, M. A., Messer, S. A., Hollis, R. J., Jones, R. N., Doern, G. V., Brandt, M. E. & Hajjeh, R. A. ( 1999;). Trends in species distribution and susceptibility to fluconazole among blood stream isolates of Candida species in the United States. Diagn Microbiol Infect Dis 33, 217–222.[CrossRef]
    [Google Scholar]
  11. Powderly, W. G. ( 1994;). Resistant candidiasis. AIDS Res Hum Retrovir 10, 925–929.[CrossRef]
    [Google Scholar]
  12. Powderly, W. G., Kobayashi, G. S., Herzig, G. P. & Medoff, G. ( 1988;). Amphotericin B-resistant yeast infection in severely immunocompromised patients. Am J Med 84, 826. 826.[CrossRef]
    [Google Scholar]
  13. Randhawa, H. S. & Khan, Z. U. ( 1987;). Acute pulmonary mycoses in India: current status and laboratory diagnosis aspects. Indian J Tuberc 34, 3–11.
    [Google Scholar]
  14. Rex, J. H., Pfaller, M. A., Rinaldi, M. G., Polak, A. & Galgiani, J. N. ( 1993;). Antifungal susceptibility testing. Clin Microbiol Rev 6, 367–381.
    [Google Scholar]
  15. Rex, J. H., Cooper, C. R., Merz, W. G., Galgiani, J. N. & Anaissie, E. J. ( 1995;). Detection of amphotericin B-resistant Candida isolates in a broth-based system. Antimicrob Agents Chemother 39, 906–909.[CrossRef]
    [Google Scholar]
  16. Sharma, G. L., Dabur, R. & Ali, M. ( 2004). A novel antifungal molecule 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrol-2-yl)-1-methylethyl pentanoate. US patent no. 6713504.
  17. Zhanel, G. G., Karlowsky, J. A., Harding, G. A. J., Balko, T. V., Zelenitsky, S. A., Friesen, M., Kabani, A., Turik, M. & Hoban, D. J. ( 1997;). In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother 41, 863–865.
    [Google Scholar]
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