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Volume 54, Issue 1

Depletion of lymphocytes, but not neutrophils, via apoptosis in a murine model of infection No Access

Abstract

causes severe sepsis in humans. There are several reports about the relationship between host immunity and bacterial growth in infection. However, the effect on leukocytes of infection has not been elucidated. A murine model of infection was used to investigate its effects on leukocytes in this study. Bacteria were recovered from the blood of mice 3 h after subcutaneous injection in the right lower flank. They were detected in 87.5 % ( = 7/8) of mice at 6 h, but this value decreased to 12.5 % ( = 1/8) at 12 h. In contrast, the number of lymphocytes in peripheral blood had already started to decrease at 3 h, and reached a minimum at 6–9 h post-inoculation. Typical DNA laddering, a hallmark of apoptosis, was also detected in thymocytes and splenocytes at 6 and 9 h, and showed a tendency to disappear by 12 h. Although the number of lymphocytes decreased in the model, the numbers of neutrophils did not. These results suggested that has selective cytotoxicity for lymphocytes in peripheral blood , and the lymphocyte depletion was probably associated with apoptosis .

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/content/journal/jmm/10.1099/jmm.0.45861-0
2005-01-01
2025-04-18
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/content/journal/jmm/10.1099/jmm.0.45861-0
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Depletion of lymphocytes, but not neutrophils, via apoptosis in a murine model of Vibrio vulnificus infection
J. Med. Microbiol. 54, 15 (2005); https://doi.org/10.1099/jmm.0.45861-0
/content/journal/jmm/10.1099/jmm.0.45861-0
/content/journal/jmm/10.1099/jmm.0.45861-0
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