1887

Abstract

At the Istituto Ricovero Cura Carattere Scientifico, Ospedale Maggiore di Milano, Italy, accounted for 3.3 and 4.4 % of all species other than collected during 1996 and 1998, respectively. Genetic variability was investigated by electrophoretic karyotyping and inter-repeat PCR, and the susceptibility to five antifungal agents of 46 strains isolated from 37 patients during these 2 years was determined. Combination of the two typing methods yielded 14 different DNA types. Although the majority of DNA types were randomly distributed among different units, one DNA type was significantly more common in patients hospitalized in a given unit compared with those from other wards ( = 0.034), whereas another DNA type was more frequently isolated in patients hospitalized during 1996 than in those hospitalized during 1998 ( = 0.002). Fluconazole, itraconazole and posaconazole MIC values were 16, 1 and 4 μg ml, respectively. All isolates but three were susceptible to flucytosine. All isolates were susceptible to amphotericin B. These data suggest that there are possible relationships among strains of , wards and time of isolation. Amphotericin B seems to be the optimal drug therapy in infections due to this yeast species.

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2005-03-01
2024-12-12
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References

  1. Alter S. J., Farley J. 1994; Development of Hansenula anomala infection in a child receiving fluconazole therapy. Pediatr Infect Dis J 13:158–159 [CrossRef]
    [Google Scholar]
  2. Barchiesi F., Hollis R. J., McGough D. A., Scalise G., Rinaldi M. G., Pfaller M. A. 1995; DNA subtypes and fluconazole susceptibilities of Candida albicans isolates from the oral cavities of patients with AIDS. Clin Infect Dis 20:634–640 [CrossRef]
    [Google Scholar]
  3. Barchiesi F., Torturano A. M., Falconi Di Francesco L., Cogliati M., Scalise G., Viviani M. A. 1999; In-vitro activity of five antifungal agents against uncommon clinical isolates of Candida spp. J Antimicrob Chemother 43:295–299 [CrossRef]
    [Google Scholar]
  4. Goss G., Grigg A., Rathbone P., Slavin M. 1994; Hansenula anomala infection after bone marrow transplantation. Bone Marrow Transplant 14:995–997
    [Google Scholar]
  5. Haron E., Anaissie E., Dumphy F., McCredie K., Fainstein V. 1988; Hansenula anomala fungemia. Rev Infect Dis 10:1182–1186 [CrossRef]
    [Google Scholar]
  6. Hazen K. C. 1995; New and emerging yeast pathogens. Clin Microbiol Rev 8:462–478
    [Google Scholar]
  7. Hirasaki S., Ijichi T., Fujita N., Araki S., Gotoh H., Nakagawa M. 1992; Fungemia caused by Hansenula anomala : successful treatment with fluconazole. Intern Med 31:622–624 [CrossRef]
    [Google Scholar]
  8. Klein A. S., Tortora G. T., Malowitz R., Greene W. H. 1988; Hansenula anomala : a new fungal pathogen.Two case reports and a review of the literature. Arch Intern Med 148:1210–1213 [CrossRef]
    [Google Scholar]
  9. Kunova A., Spanik S., Kollar T., Krcmery V. Jr 1996; Breakthrough fungemia due to Hansenula anomala in a leukemia patient successfully treated with amphotericin B. J Chemother 8:85–86 [CrossRef]
    [Google Scholar]
  10. Kwon-Chung K. J., Bennett J. E. 1992; Candidiasis. In Medical Mycology pp 280–336 Edited by Kwon-Chung K. J., Bennett J. E. Philadelphia: Lea & Febiger;
    [Google Scholar]
  11. Lehmann P. F., Lin D., Lasker D. A. 1992; Genotypic identification and characterization of species and strains within the genus Candida by using random amplified polymorphic DNA. J Clin Microbiol 30:3249–3254
    [Google Scholar]
  12. Munoz P., Garcia-Leoni M. E., Berenguer J., Bernaldo-de-Quiros J. C., Bouza E. 1989; Catheter-related fungemia by Hansenula anomala . Arch Intern Med 149:709–713 [CrossRef]
    [Google Scholar]
  13. Murphy N., Buchanan C. R., Damjanovic V., Whitaker R., Hart C. A., Cooke R. W. 1986; Infection and colonisation of neonates by Hansenula anomala . Lancet i:291–293
    [Google Scholar]
  14. NCCLS 2002 Reference method for broth dilution antifungal susceptibility testing of yeasts . Approved standard M27-A2 Wayne, PA: National Committee for Clinical Laboratory Standards;
    [Google Scholar]
  15. Neumeister B., Rockemann M., Marre R. 1992; Fungaemia due to Candida pelliculosa in a case of acute pancreatitis. Mycoses 35:309–310
    [Google Scholar]
  16. Nohinek B., Zee-Cheng C. S., Barnes W. G., Dall L., Gibbs H. R. 1987; Infective endocarditis of a bicuspid aortic valve caused by Hansenula anomala . Am J Med 82:165–168 [CrossRef]
    [Google Scholar]
  17. Pfaller M. A. 1994; Epidemiology and control of fungal infections. Clin Infect Dis 19 (Suppl. 1):S8–S13 [CrossRef]
    [Google Scholar]
  18. Qadri S. M., Al-Dayel F., Strampfer M. J., Cunha B. A. 1988; Urinary tract infection caused by Hansenula anomala . Mycopathologia 104:99–101
    [Google Scholar]
  19. Salesa R., Burgos A., Fernandez-Mazarrasa C., Quindos G., Ponton J. 1991; Transient fungaemia due to Candida pelliculosa in a patient with AIDS. Mycoses 34:327–329
    [Google Scholar]
  20. Scherer S., Stevens D. A. 1987; Application of DNA typing methods to epidemiology and taxonomy of Candida species. J Clin Microbiol 25:675–679
    [Google Scholar]
  21. Sekhon A. S., Kowalewska-Grochowska K., Garg A. K., Vaudry W. 1992; Hansenula anomala fungemia in an infant with gastric and cardiac complications with a review of the literature. Eur J Epidemiol 8:305–308
    [Google Scholar]
  22. Sneath P. H. A. 1973; Numerical taxonomy. In The Principle and Practice of Numerical Classification pp 230–234 Edited by Sneath P. H. A., Sokal R. R. San Francisco: W. H. Freeman;
    [Google Scholar]
  23. Taylor G. D., Buchanan-Chell M., Kirkland T., McKenzie M., Wiens R. 1994; Trends and sources of nosocomial fungaemia. Mycoses 37:187–190 [CrossRef]
    [Google Scholar]
  24. Thuler L. C., Faivichenco S., Velasco E., Martins C. A., Nascimento C. R., Castilho I. A. 1997; Fungaemia caused by Hansenula anomala – an outbreak in a cancer hospital. Mycoses 40:193–196 [CrossRef]
    [Google Scholar]
  25. van Belkum A., Melchers W., de Pauw B. E., Scherer S., Quint W., Meis J. F. 1994; Genotypic characterization of sequential Candida albicans isolates from fluconazole-treated neutropenic patients. J Infect Dis 169:1062–1070 [CrossRef]
    [Google Scholar]
  26. Vassart G., Georges M., Monsieur R., Brocas H., Lequarre A. S., Christopher D. 1985; A sequence in M13 phage detects hypervariable minisatellites in humans and animal DNA. Science 235:683–684
    [Google Scholar]
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