1887

Abstract

The objective of this study was to investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who presented with acute otitis media (AOM) or otitis media that recurred after amoxicillin therapy. Nasopharyngeal cultures obtained from 72 patients, 40 with AOM and 32 with recurrent otitis media (ROM), were analysed. Thirty-six potentially pathogenic organisms were recovered in 34 (85 %) of the children from the AOM group, and 42 were isolated from 29 (91 %) of the children from the ROM group. The organisms isolated were ( = 26), non-type b ( = 22), ( = 13), ( = 8) and ( = 9). Resistance to the eight antimicrobial agents used was found in 37 instances in the AOM group as compared to 99 instances in the ROM group ( < 0.005). The difference between AOM and ROM was significant with resistance to amoxicillin ( < 0.005), to amoxicillin/clavulanate ( < 0.005), to trimethoprim/sulfamethoxazole ( < 0.01), to cefixime ( < 0.01) and to azithromycin ( < 0.01), and for resistance to amoxicillin ( < 0.025). These data illustrate the higher recovery rate of antimicrobial-resistant and from the nasopharynx of children who had otitis media that recurred after amoxicillin therapy than those with AOM.

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2005-01-01
2019-11-21
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