1887

Abstract

Aspiration of oropharyngeal bacteria and fungi is occasionally suspected in patients with pneumonia. A patient with oral carcinoma underwent chemoradioimmunotherapy and, about 4 weeks from the start of the therapy, the patient suffered from severe oral mucositis induced by chemoradiotherapy, and candidal pneumonia was subsequently induced. The candidal pneumonia was insufficiently improved by potent antifungal drugs, taking a lethal course. Randomly amplified polymorphic DNA analysis and DNA sequence examination of strains isolated from the oral cavity 1 week before the onset of pneumonia and autopsied lung revealed the identity of both strains as , and the DNA analysis supported aspiration of oral . These results indicate that the pathogen of the pneumonia, , was aspirated from the oral cavity and that oral is easily aspirated and becomes the pathogen of pneumonia.

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2005-05-01
2019-11-21
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