%0 Journal Article %A Bruun, Brita %A Gahrn-Hansen, Bente %A Westh, Henrik %A Kilian, Mogens %T Clonal relationship of recent invasive Haemophilus influenzae serotype f isolates from Denmark and the United States %D 2004 %J Journal of Medical Microbiology, %V 53 %N 11 %P 1161-1165 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.45749-0 %I Microbiology Society, %X Surveillance performed after the introduction of general Haemophilus influenzae serotype b (Hib) vaccination in Denmark identified 13 cases of invasive bacteraemic H. influenzae serotype f (Hif) disease in adults over a period of 7 years. Bacteraemic respiratory tract infections accounted for 61 % of cases, but meningitis, epiglottitis and osteoarthritis were also seen. Recent Danish isolates were compared to recent American isolates, historical Hif strains and non-Hif invasive strains. Results of conventional serotyping were confirmed by PCR detection of the serotype-f-specific cap and bexA gene sequences. Multilocus enzyme electrophoresis typing revealed that recent Danish and American isolates belonged to a single Hif clone, which may be undergoing expansion. The need for accurate serotyping of H. influenzae to enable reliable monitoring for Hib replacement by other capsular types is emphasized. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.45749-0