1887

Abstract

Surveillance performed after the introduction of general serotype b (Hib) vaccination in Denmark identified 13 cases of invasive bacteraemic serotype f (Hif) disease in adults over a period of 7 years. Bacteraemic respiratory tract infections accounted for 61 % of cases, but meningitis, epiglottitis and osteoarthritis were also seen. Recent Danish isolates were compared to recent American isolates, historical Hif strains and non-Hif invasive strains. Results of conventional serotyping were confirmed by PCR detection of the serotype-f-specific and gene sequences. Multilocus enzyme electrophoresis typing revealed that recent Danish and American isolates belonged to a single Hif clone, which may be undergoing expansion. The need for accurate serotyping of to enable reliable monitoring for Hib replacement by other capsular types is emphasized.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.45749-0
2004-11-01
2019-11-18
Loading full text...

Full text loading...

/deliver/fulltext/jmm/53/11/JM531118.html?itemId=/content/journal/jmm/10.1099/jmm.0.45749-0&mimeType=html&fmt=ahah

References

  1. Adderson, E. E., Byington, C. L., Spencer, L. S. & 7 other authors ( 2001;). Invasive serotype a Haemophilus influenzae infections with a virulence genotype resembling Haemophilus influenzae type b: emerging pathogen in the vaccine era? Pediatrics 108, e18. e18.[CrossRef]
    [Google Scholar]
  2. Anyanwu, J. N., Rodriguez, C. A., Fleming, K. E. & Adderson, E. E. ( 2003;). pgi genotyping is a surrogate for serotyping of encapsulated Haemophilus influenzae. J Clin Microbiol 41, 2080–2083.[CrossRef]
    [Google Scholar]
  3. Campos, J. ( 2001;). Haemophilus influenzae: from the post-vaccination era to antibiotic resistance. Clin Microbiol Infect 7, 287–290.
  4. Campos, J., Roman, F., Perez-Vazquez, M., Aracil, B., Oteo, J., Cercenado, E. & the Spanish Study Group for H. influenzae type f ( 2003; ). Antibiotic resistance and clinical significance of Haemophilus influenzae type f. J Antimicrob Chemother 52, 961–966.[CrossRef]
    [Google Scholar]
  5. Cerquetti, M., degli Atti, M. L., Cardines, R., Salmaso, S., Renna, G. & Mastrantonio, P. ( 2003;). Invasive type e Haemophilus influenzae disease in Italy. Emerg Infect Dis 9, 258–261.[CrossRef]
    [Google Scholar]
  6. Falla, T. J., Crook, D. W., Brophy, L. N., Maskell, D., Kroll, J. S. & Moxon, E. R. ( 1994;). PCR for capsular typing of Haemophilus influenzae. J Clin Microbiol 32, 2382–2386.
    [Google Scholar]
  7. Kilian, M. ( 1976;). A taxonomic study of the genus Haemophilus, with the proposal of a new species. J Gen Microbiol 93, 9–262.[CrossRef]
    [Google Scholar]
  8. Kroll, J. S., Moxon, E. R. & Loynds, B. M. ( 1994;). Natural genetic transfer of a putative virulence-enhancing mutation to Haemophilus influenzae type a. J Infect Dis 169, 676–679.[CrossRef]
    [Google Scholar]
  9. Kumar, S., Tamura, K., Jacobsen, L. B. & Nei, M. ( 2001;). MEGA2: Molecular Evolutionary Genetics Analysis software. Bioinformatics 17, 1244–1245.[CrossRef]
    [Google Scholar]
  10. LaClaire, L. L., Tondella, M. L. C., Beall, D. S., Noble, C. A., Raghunathan, P. L., Rosenstein, N. E., Popovic, T. & the Active Bacterial Core Surveillance Team Members ( 2003;). Identification of Haemophilus influenzae serotypes by standard slide agglutination serotyping and PCR-based capsule typing. J Clin Microbiol 41, 393–396.[CrossRef]
    [Google Scholar]
  11. Maynard Smith, J. ( 1995;). Do bacteria have population genetics? In Population Genetics of Bacteria (Society for General Microbiology Symposium no. 52), pp. 1–12. Edited by S. Baumberg, J. P. W. Young, E. M. H. Wellington & J. R. Saunders. Cambridge: Cambridge University Press.
  12. Musser, J. M., Kroll, J. S., Moxon, E. R. & Selander, R. F. ( 1988;). Evolutionary genetics of the encapsulated strains of Haemophilus influenzae. Proc Natl Acad Sci U S A 85, 7758–7762.[CrossRef]
    [Google Scholar]
  13. Musser, J. M., Kroll, J. S., Granoff, D. M. & 25 other authors ( 1990;). Global genetic structure and molecular epidemiology of encapsulated Haemophilus influenzae. Rev Infect Dis 12, 75–111.[CrossRef]
    [Google Scholar]
  14. Ogilvie, C., Omikunle, A., Wang, Y., St Geme, J. W., III, Rodriguez, C. A. & Adderson, E. E. ( 2001;). Capsulation loci of non-serotype b encapsulated Haemophilus influenzae. J Infect Dis 184, 144–149.[CrossRef]
    [Google Scholar]
  15. Omikunle, A., Takahashi, S., Ogilvie, C. L., Wang, Y., Rodriguez, C. A., St Geme, J. W., III & Adderson, E. E. ( 2002;). Limited genetic diversity of recent invasive isolates of non-serotype b encapsulated Haemophilus influenzae. J Clin Microbiol 40, 1264–1270.[CrossRef]
    [Google Scholar]
  16. Perdue, D. G., Bulkow, L. R., Gellin, B. G., Davidson, M., Petersen, K. M., Singleton, R. J. & Parkinson, A. J. ( 2000;). Invasive Haemophilus influenzae disease in Alaskan residents aged 10 years and older before and after infant vaccination programs. JAMA (J Am Med Assoc) 283, 3089–3094.[CrossRef]
    [Google Scholar]
  17. Ribeiro, G. S., Reis, J. N., Cordeiro, S. M. & 10 other authors ( 2003;). Prevention of Haemophilus influenzae Type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. J Infect Dis 187, 109–116.[CrossRef]
    [Google Scholar]
  18. Selander, R. K., Caugant, D. A., Ochman, H., Musser, J. M., Gilmour, M. N. & Whittam, T. S. ( 1986;). Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics. Appl Environ Microbiol 51, 873–884.
    [Google Scholar]
  19. Slater, L. N., Guarnaccia, J., Makintubee, S. & Istre, G. R. ( 1990;). Bacteremic disease due to Haemophilus influenzae capsular type f in adults: report of five cases and review. Rev Infect Dis 12, 628–635.[CrossRef]
    [Google Scholar]
  20. Urwin, G., Krohn, J. A., Deaver-Robinson, K., Wenger, J. D. & Farley, M. M. ( 1996;). Invasive disease due to Haemophilus influenzae serotype f: clinical and epidemiologic characteristics in the H.influenzae serotype b vaccine era. Clin Infect Dis 22, 1069–1076.[CrossRef]
    [Google Scholar]
  21. Van Alphen, L., Geelen, L., Jonsdottir, K., Takala, A. K., Käyhty, H. & Zanen, H. C. ( 1987;). Distinct geographic distribution of subtypes of Haemophilus influenzae type b in western Europe. J Infect Dis 156, 216–218.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.45749-0
Loading
/content/journal/jmm/10.1099/jmm.0.45749-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error