1887

Abstract

Surveillance performed after the introduction of general serotype b (Hib) vaccination in Denmark identified 13 cases of invasive bacteraemic serotype f (Hif) disease in adults over a period of 7 years. Bacteraemic respiratory tract infections accounted for 61 % of cases, but meningitis, epiglottitis and osteoarthritis were also seen. Recent Danish isolates were compared to recent American isolates, historical Hif strains and non-Hif invasive strains. Results of conventional serotyping were confirmed by PCR detection of the serotype-f-specific and gene sequences. Multilocus enzyme electrophoresis typing revealed that recent Danish and American isolates belonged to a single Hif clone, which may be undergoing expansion. The need for accurate serotyping of to enable reliable monitoring for Hib replacement by other capsular types is emphasized.

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2004-11-01
2024-03-28
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