1887

Abstract

Group A streptococcus (GAS) infection can cause severe invasive diseases, including necrotizing fasciitis and streptococcal toxic shock syndrome. , a Chinese herbal medicine, is an immunomodulator. In this study the air-pouch bacterial inoculation model was used to investigate the protective efficacy of mycelium extract against GAS infection. Force-feeding mice with mycelium extract for 3 consecutive days before GAS infection increased the survival rate and reduced local skin-tissue injury compared with mice fed PBS. Bacterial numbers in the air pouch exudates from -treated mice were lower than those from PBS-treated mice. Blood and organs in PBS-treated mice showed bacterial dissemination, but those in -treated mice did not. Three days of pretreatment with extract followed by treatment every other day after GAS infection resulted in 100 % survival. The post-GAS-infection levels of aspartate aminotransferase, alanine aminotransferase and blood urea nitrogen in the sera of -treated mice were lower than those of PBS-treated mice. Taken together, these results show that mycelium extract protects by decreasing bacterial growth and dissemination, thereby increasing mouse survival rate. IL-12 and IFN-γ expression and macrophage phagocytic activity also increased after treatment.

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2005-08-01
2019-11-18
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