%0 Journal Article %A Dam, T %A Isa, M %A Bose, M %T Drug-sensitivity profile of clinical Mycobacterium tuberculosis isolates – a retrospective study from a chest-disease institute in India %D 2005 %J Journal of Medical Microbiology, %V 54 %N 3 %P 269-271 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.45635-0 %I Microbiology Society, %X Multi-drug-resistant tuberculosis (MDR-TB) is a major public-health problem, because treatment is complicated and patients remain infectious for months or years, despite receiving the best available therapy. To gain better understanding of MDR-TB, a retrospective study was initiated to determine the level of drug resistance among patients in a chest-disease institute in India. Two hundred and sixty-three isolates from treatment-failure pulmonary tuberculosis patients (20–70 years) were studied. Drug-sensitivity testing was performed by the modified-proportion method. First- and second-line drugs, along with two quinolone drugs (ofloxacin and ciprofloxacin), were tested. Patients included in this study did not improve with therapy; however, 151 isolates (57.5 %) were susceptible to all four first-line antituberculosis drugs. This study reports low resistance to fluoroquinolones among the strains present in these patients. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.45635-0