1887

Abstract

Multi-drug-resistant tuberculosis (MDR-TB) is a major public-health problem, because treatment is complicated and patients remain infectious for months or years, despite receiving the best available therapy. To gain better understanding of MDR-TB, a retrospective study was initiated to determine the level of drug resistance among patients in a chest-disease institute in India. Two hundred and sixty-three isolates from treatment-failure pulmonary tuberculosis patients (20–70 years) were studied. Drug-sensitivity testing was performed by the modified-proportion method. First- and second-line drugs, along with two quinolone drugs (ofloxacin and ciprofloxacin), were tested. Patients included in this study did not improve with therapy; however, 151 isolates (57.5 %) were susceptible to all four first-line antituberculosis drugs. This study reports low resistance to fluoroquinolones among the strains present in these patients.

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/content/journal/jmm/10.1099/jmm.0.45635-0
2005-03-01
2019-11-17
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References

  1. Balows, A., Hausler, W. J., Jr, Herrmann, K. L., Isenberg, H. D. & Shadomy, H. J. (editors) ( 1991;). Manual of Clinical Microbiology, 5th edn. Washington, DC: American Society for Microbiology.
  2. Hemvani, N., Chitnis, D. S., Bhatia, G. C. & Sharma, N. ( 2001;). Drug resistance among tubercle bacilli from pulmonary tuberculosis cases in central India. Indian J Med Sci 55, 382–392.
    [Google Scholar]
  3. Mathur, M. L., Khatri, P. K. & Base, C. S. ( 2000;). Drug resistance in tuberculosis patients in Jodhpur district. Indian J Med Sci 54, 55–58.
    [Google Scholar]
  4. Paramasivan, C. N., Venkataraman, P., Chandrasekaran, V., Bhat, S. & Narayanan, P. R. ( 2002;). Surveillance of drug resistance in tuberculosis in two districts of South India. Int J Tuberc Lung Dis 6, 479–484.
    [Google Scholar]
  5. Shah, A. R., Agarwal, S. K. & Shah, K. V. ( 2002;). Study of drug resistance in previously treated tuberculosis patients in Gujrat, India. Int J Tuberc Lung Dis 6, 1098–1101.
    [Google Scholar]
  6. Udwadia, Z. F. ( 2001;). India's multidrug-resistant tuberculosis crisis. Ann N Y Acad Sci 953, 98–105.
    [Google Scholar]
  7. Vijay, S., Balasangameshwara, V. H., Jagannatha, P. S., Saroja, V. N., Shivashankar, B. & Jagota, P. ( 2002;). Re-treatment outcome of smear positive tuberculosis cases under DOTs in Bangalore city. Indian J Tuberc 49, 195–204.
    [Google Scholar]
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