1887

Abstract

Recognition of bacterial lipopolysaccharide (LPS) is critical in the host defence against Gram-negative infection. While enterobacterial LPS signals via Toll-like receptor 4 (TLR4), it has recently been reported that the LPS of , , species Sin-1 and at least one strain of are capable of signalling via TLR2. Using a TLR transfection assay and measurement of an NF-κB-sensitive promoter region, the results show that the LPS of NCTC-9343, LGV-1 and PAC-611 also signal via TLR2 and it is pointed out that all TLR2-signalling LPS discovered to date demonstrate relatively weak endotoxicity in some models and structural features distinct from those LPS shown to signal via TLR4.

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2004-08-01
2021-01-20
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