1887

Abstract

Indigenous intestinal microflora (including lactobacilli) has an important role in protection against infection. To assess interaction between lactobacilli and , antagonistic activity of 50 intestinal spp. strains against 23 pathogenic strains was determined. Phenotypic properties of strains [production of short-chain fatty acids (SCFAs) and toxin A, and antimicrobial susceptibility] and lactobacilli (production of SCFAs and HO) were investigated. Five lactobacilli ( and species) were antagonistic to all strains, 18 were antagonistic to some strains and 27 showed no antagonistic activity. This antagonistic activity was strain-specific and seemed to correlate with HO and lactic acid production. strains that were more sensitive to lactobacilli ( = 9) usually produced higher toxin levels and more SCFAs, and were more resistant to antibiotics, than strains that were resistant to lactobacilli ( = 14). Compatibility of strain properties (resistance to lactobacilli or antibiotics) with intestinal microecological conditions (e.g. presence of antagonistic lactobacilli, concentration of antibiotics) may determine expression of disease.

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2004-06-01
2020-10-27
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