1887

Abstract

The first investigation of isolated from a large area covering an appreciable population in Portugal, before the voluntary vaccination period with the serogroup C conjugate vaccine, is reported. The serogroups and antimicrobial susceptibility of 116 isolates were studied. Serogroups C (50.0 %), B (47.4 %) and W135 (2.6 %) were found. Serogroup C was most common in the 1–15-years-old group and B in the less than 1-year-old and over 16-years-old groups ( = 0.042). Clinical diagnosis of meningococcal disease was primarily meningitis for patients with serogroup C and meningitis associated with sepsis for those with serogroup B. Penicillin resistance was significantly associated with serogroup C ( < 0.001). This work reinforces the importance for public health of monitoring the serogroup and antimicrobial susceptibility of isolates from patients with invasive meningococcal disease.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.45556-0
2004-09-01
2021-04-10
Loading full text...

Full text loading...

/deliver/fulltext/jmm/53/9/JM530914.html?itemId=/content/journal/jmm/10.1099/jmm.0.45556-0&mimeType=html&fmt=ahah

References

  1. Arreaza L., de La Fuente L., Vázquez J. 2000; Antibiotic susceptibility patterns of Neisseria meningitidis isolates from patients and asymptomatic carriers. Antimicrob Agents Chemother 44:1705–1707 [CrossRef]
    [Google Scholar]
  2. Blanco M., Queirós L., Gonçalves G., Freitas J. 2000; Doença meningocócica no distrito do Porto.Alertas pelo Sistema de Alerta e Resposta Apropriada (SARA. Saúde em Números 15:29–32 (in Portuguese
    [Google Scholar]
  3. Blondeau J. M., Ashton F. E., Isaacson M., Yaschuck Y., Anderson C., Ducasse G. 1995; Neisseria meningitidis with decreased susceptibility to penicillin in Saskatchewan, Canada. J Clin Microbiol 33:1784–1786
    [Google Scholar]
  4. Cartwright K. A. V., Jones D. M., Smith A. J., Stuart J. M., Kaczmarski E. B., Palmer S. R. 1991; Influenza A and meningococcal disease. Lancet 338:554–557 [CrossRef]
    [Google Scholar]
  5. Carvalho L. 2002; Infecção invasiva a meningococos e pneumococos na U. D. I. do H. D. Estefânia. In Simposium Wyeth Lederle Portugal: Infecção invasiva a pneumococos e meningococos Lisbon, Portugal: (in Portuguese)
    [Google Scholar]
  6. Connolly M., Noah N. 1999; Is group C meningococcal disease increasing in Europe? A report of surveillance of meningococcal infection in Europe 1993–6.European Meningitis Surveillance Group. Epidemiol Infect 122:41–49 [CrossRef]
    [Google Scholar]
  7. Cunha F., Carvalho L. 1993; Meningites na criança. In Temas de Pediatria, Patologia Infecciosa . Monografia Beecham vol2 pp 169–185 (in Portuguese
    [Google Scholar]
  8. DGS 2003; Estatísticas. Doenças de declaração obrigatória 1998/2002: quadros por doença, região e sub-região, sexo e grupo etário, mês. Direcção-Geral da Saúde; 1998/2002 pp 17–18 http://www2.dgsaude.pt/upload/membro.id/ficheiros/i005838.pdf (in Portuguese)
    [Google Scholar]
  9. Ferreira E., Caniça M. 2002; Invasive meningococci with reduced susceptibility to penicillin in Portugal. J Antimicrob Chemother 49:424–425 [CrossRef]
    [Google Scholar]
  10. Ferreira E., Caniça M. M. & The Multicentre Study Group (199). (GEMVSA) . Emergence of Neisseria meningitidis serogroup C and reduced susceptibility to penicillin in Portugal isolates. In Abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy p– 171 Washington, DC: American Society for Microbiology;
    [Google Scholar]
  11. Ferreira E., Caniça M. Grupo de Estudos Multicêntricos de Vigilância da Susceptibilidade aos Antibióticos (200)(GEMVSA) & Susceptibilidade aos antibióticos e caracterização dos serogroups de Neisseria meningitidis . Rev Port Doenças Infecciosas 24:5–10 (in Portuguese)
    [Google Scholar]
  12. Gomes M. C., Ferreira M. M., Gonçalves A. G., Valente P. M., Freitas M. G. Restantes Membros da Comissão Técnica de Vacinação 2001; Doença meningocócica em Portugal: epidemiologia e vacinação. Saúde em Números 16:1–11 (in Portuguese
    [Google Scholar]
  13. Healy C. M., Butler K. M., Smith E. O., Hensey O. P., Bate T., Moloney A. C., MacMahon P., Cosgrove J., Cafferkey M. 2002; Influence of serogroup on the presentation, course, and outcome of invasive meningococcal disease in children in the Republic of Ireland, 1995–2000. Clin Infect Dis 34:1323–1330 [CrossRef]
    [Google Scholar]
  14. Holten E., Froholm L. O., Gaustad P. 1984; Virulence markers in patient and carrier strains of Neisseria meningitidis . Scand J Infect Dis 16:267–270 [CrossRef]
    [Google Scholar]
  15. Noah N., Henderson B. 2001; Surveillance of bacterial meningitis in Europe 1999/2000 . Communicable Disease Surveillance Centre. PHLS, UK:
  16. Pollard A. J., Britto J., Nadel S., DeMunter C., Habibi P., Levin M. 1999; Emergency management of meningococcal disease. Arch Dis Child 80:290–296 [CrossRef]
    [Google Scholar]
  17. Santos L., Simões J., Fonseca A. F., Lecour H. 2003; Meningitis by N. meningitidis . In Abstracts of the 7th Meeting of the European Monitoring Group on Meningococci p– 32 Edited by EMGM/Instituto de Salud Carlos III
    [Google Scholar]
  18. Taha M. K. 2000; Simultaneous approach for nonculture PCR-based identification and serogroup prediction of Neisseria meningitidis . J Clin Microbiol 38:855–857
    [Google Scholar]
  19. WHO 1998; Antimicrobial and support therapy for bacterial meningitis in children. Report of the meeting of 18–20, June 1997; World Health Organization http://www.who.int/csr/resources/publications/meningitis/whoemcbac982.pdf
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.45556-0
Loading
/content/journal/jmm/10.1099/jmm.0.45556-0
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error