1887

Abstract

Coccidioidal pericarditis is a condition found in approximately 1–5 % of patients infected by species. It is associated with widely diverse clinical symptoms. This paper reports a case of coccidioidal pericarditis diagnosed by an in-house antigen and confirmed with mycological and molecular methods. From February to September 2005, the patient suffered from fever, weight loss, a non-productive cough, thoracic pain and tachycardia. He received a positive diagnosis of coccidioidal pericarditis only in October 2005. The macromorphological examination of the culture showed a whitish felt-like colony, which became brownish with age. Preparations in lactophenol cotton blue stain showed hyaline septate hyphae with fragmentation and thin arthroconidia-like structures. Pericardial fluid and sera samples were positive for antibodies by immunodiffusion and ELISA with a in-house antigen preparation. The identification was confirmed by nested PCR of the antigen 2/proline-rich antigen (Ag2/PRA) encoding gene.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.2008/002428-0
2008-10-01
2021-03-03
Loading full text...

Full text loading...

/deliver/fulltext/jmm/57/10/1288.html?itemId=/content/journal/jmm/10.1099/jmm.0.2008/002428-0&mimeType=html&fmt=ahah

References

  1. Aquilar J. A., Summerson C., Granda M. C., Jiménez C., De La Torre S. 2001; Pericarditis caused by coccidioidomycosis. Report of a case. Arch Cardiol Mex 71:313–318 (in Spanish)
    [Google Scholar]
  2. Arsura E. L., Bobba R. K., Reddy C. M. 2005; Coccidioidal pericarditis: a case presentation and review of the literature. Int J Infect Dis 9:104–109 [CrossRef]
    [Google Scholar]
  3. Assi M. A., Binnicker M. J., Wengenack N. L., Deziel P. J., Badley A. D. 2006; Disseminated coccidioidomycosis in a liver transplant recipient with negative serology: use of polymerase chain reaction. Liver Transpl 12:1290–1292 [CrossRef]
    [Google Scholar]
  4. Bialek R., Kern J., Herrmann T., Tijerina R., Ceceñas L., Reischl U., González G. M. 2004; PCR assays for identification of Coccidioides posadasii based on the nucleotide sequence of the antigen 2/proline-rich antigen. J Clin Microbiol 42:778–783 [CrossRef]
    [Google Scholar]
  5. Burt A., Carter D. A., Kloenig G. L., White T. J., Taylor J. T. 1995; A safe method of extracting DNA from Coccidioides immitis . Fungal Genet Newsl 42:23
    [Google Scholar]
  6. Camargo Z. P., Berzaghi R., Amaral C. C., Silva S. H. 2003; Simplified method for producing Paracoccidioides brasiliensis exoantigens for use in immunodiffusion tests. Med Mycol 41:539–542 [CrossRef]
    [Google Scholar]
  7. Chowdhury J. K., Habibzadeh M. A. 1977; Disseminated coccidioidomycosis with pericarditis. Chest 71:533–535 [CrossRef]
    [Google Scholar]
  8. Clemons K. V., Capilla J., Stevens D. A. 2007; Experimental animal models of coccidioidomycosis. Ann N Y Acad Sci 1111208–224 [CrossRef]
    [Google Scholar]
  9. Cordeiro R. A., Brilhante R. S. N., Rocha M. F. G., Fechine M. A. B., Camara L. M. C., Camargo Z. P., Sidrim J. J. C. 2006a; Phenotypic characterization and ecological features of Coccidioides spp. from Northeast Brazil. Med Mycol 44:631–639 [CrossRef]
    [Google Scholar]
  10. Cordeiro R. A., Brilhante R. S. N., Rocha M. F. G., Fechine M. A. B., Camargo Z. P., Sidrim J. J. C. 2006b; In vitro inhibitory effect of antituberculosis drugs on clinical and environmental strains of Coccidioides posadasii . J Antimicrob Chemother 58:575–579 [CrossRef]
    [Google Scholar]
  11. Cordeiro R. A., Brilhante R. S. N., Rocha M. F. G., Fechine M. A. B., Costa A. K. F., Camargo Z. P., Sidrim J. J. C. 2006c; In vitro activities of caspofungin, amphotericin B and azoles against Coccidioides posadasii strains from Northeast. Brazil. Mycopathologia 161:21–26 [CrossRef]
    [Google Scholar]
  12. Crum-Cianflone N. F., Truett A. A., Teneza-Mora N., Maves R. C., Chun H. M., Bavaro M. F., Hale B. R. 2006; Unusual presentations of coccidioidomycosis: a case series and review of the literature. Medicine (Baltimore) 85:263–277 [CrossRef]
    [Google Scholar]
  13. De Hoog G. S., Guarro J., Gené J., Figueras M. J. 2000 Atlas of Clinical Fungi , 2nd edn. Utrecht & Reus: Centraalbureau voor Schimmelcultures and Universitat Rovira i Virgili;
    [Google Scholar]
  14. Faul J. L., Hoang K., Schmoker J., Vagelos R. H., Berry G. J. 1999; Constrictive pericarditis due to coccidioidomycosis. Ann Thorac Surg 68:1407–1409 [CrossRef]
    [Google Scholar]
  15. Fisher M. C., Koenig G. L., White T. J., Taylor J. W. 2002; Molecular and phenotypic description of Coccidioides posadasii sp. nov., previously recognized as the non-California population of Coccidoides immitis . Mycologia 94:73–84 [CrossRef]
    [Google Scholar]
  16. Galgiani J. N., Ampel N. M., Blair J. E., Catanzaro A., Johnson R. H., Stevens D. A., Williams P. L. 2005; Coccidioidomycosis. Clin Infect Dis 41:1217–1223 [CrossRef]
    [Google Scholar]
  17. Hector R. F., Laniado-Laborin R. 2005; Coccidioidomycosis – a fungal disease of the Americas. PLoS Med 2:e2 [CrossRef]
    [Google Scholar]
  18. Kolivras K. N., Johnson P. S., Comrie A. C., Yool S. R. 2001; Environmental variability and coccidioidomycosis (valley fever). Aerobiologia 17:31–42 [CrossRef]
    [Google Scholar]
  19. Pappagianis D. 2001; Serologic studies in coccidioidomycosis. Semin Respir Infect 16:242–250 [CrossRef]
    [Google Scholar]
  20. Sanguinetti C. J., Dias Neto E., Simpson A. J. G. 1994; Rapid silver staining and recovery of PCR products separated on polyacrilamide gels. Biotechniques 17:914–921
    [Google Scholar]
  21. Saubolle M. A., McKellar P. P., Sussland D. 2007; Epidemiologic, clinical, and diagnostic aspects of coccidioidomycosis. J Clin Microbiol 45:26–30 [CrossRef]
    [Google Scholar]
  22. Schwartz E. L., Waldmann E. B., Payne R. M., Goldfarb D., Kinard S. A. 1976; Coccidioidal pericarditis. Chest 70:670–672 [CrossRef]
    [Google Scholar]
  23. Sidrim J. J. C., Silva L. C. I., Nunes J. M. A., Rocha M. F. G., Paixão G. C. 1997; Le Nord-Est Brésilien, région dendémie de coccidioidomycose? A propos dune micro-épidémie. J Mycol Méd 7:37–39
    [Google Scholar]
  24. Sutton D. A. 2007; Diagnosis of coccidioidomycosis by culture: safety considerations, traditional methods, and susceptibility testing. Ann N Y Acad Sci 1111:315–325 [CrossRef]
    [Google Scholar]
  25. Talbot N. (editor) 2001 Molecular and Cellular Biology of Filamentous Fungi: a Practical Approach New York: Oxford University Press;
    [Google Scholar]
  26. Visbal A. L., DeValeria P. A., Blair J. E., Zarka M. A., Lanza L. A. 2003; Coccidioidal pericarditis: implications of surgical treatment in the elderly. Ann Thorac Surg 75:1328–1330 [CrossRef]
    [Google Scholar]
  27. Wanke B., Lazera M., Monteiro P. C. F., Lima F. C., Leal M. J. S., Ferreira Filho P. L., Kaufman L., Pinner R. W., Ajello L. 1999; Investigation of an outbreak of endemic coccidioidomycosis in Brazil’s Northeastern State of Piauí with a review of the occurrence and distribution of Coccidioides immitis in three other Brazilian states. Mycopathologia 148:57–67 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.2008/002428-0
Loading
/content/journal/jmm/10.1099/jmm.0.2008/002428-0
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error