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We describe what we believe to be the first case of neonatal sepsis caused by CTX-M-producing Escherichia coli, in a low-weight preterm infant, born to a colonized mother who had received antibiotic treatment antepartum. Increased dissemination of extended-spectrum β-lactamase-producing E. coli in the community should be borne in mind for empirical therapy of sepsis in high-risk newborns.
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