1887

Abstract

Our previous study demonstrated that Staphylococcal enterotoxin B (SEB) administration during pregnancy could alter the percentage of T cells subpopulation in the thymus of the neonatal rats; however, little is known about the effect of maternal SEB administration during pregnancy on T cells subpopulation in the peripheral blood of the offspring rats. In the present study, pregnant rats at gestational day 16 were intravenously injected with 15 µg SEB. The present study found that prenatal exposure to SEB significantly decreased the percentages of CD8 T cells in the peripheral blood of both neonatal rats on the fifth day after delivery and the adult offspring rats. Furthermore, it significantly increased the percentage of CD4 T cells as well as the ratios of CD4 to CD8 T cells in both neonatal and adult offspring rats. Prenatal exposure to SEB significantly decreased the expression levels of IL-4 and IFN-γ in the plasma of neonatal and adult offspring rats. Furthermore, SEB restimulation significantly increased the percentage of CD8 T cells and significantly decreased the percentage of CD4 T cells. These data suggest the prenatal exposure to SEB can imprint the increased CD4:CD8 T cell ratio in the peripheral blood from the neonate to adulthood through the decreased CD8 T cells and the increased CD4 T cells, and altered the response characteristics of CD4 and CD8 T cells to secondary SEB administration in the peripheral blood of the adult offspring rats.

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2015-01-01
2019-10-22
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References

  1. Barker D. J.. ( 1994;). Mothers, Babies, and Disease in Later Life. London, UK:: BMJ Publishing Group;.
    [Google Scholar]
  2. Baschieri S., Lees R. K., Lussow A. R., MacDonald H. R.. ( 1993;). Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines. . Eur J Immunol 23:, 2661–2666. [CrossRef][PubMed]
    [Google Scholar]
  3. Bell S. J., Buxser S. E.. ( 1995;). Staphylococcal enterotoxin B modulates V beta 8+ TcR-associated T-cell memory against conventional antigen. . Cell Immunol 160:, 58–64. [CrossRef][PubMed]
    [Google Scholar]
  4. Bergdoll M. S.. ( 1983;). Enterotoxins. . In Staphylococci and Staphylococcal Infections, vol. 2, pp. 559–598. Edited by Easman C. S. F., Adlam C... London:: Academic Press;.
    [Google Scholar]
  5. Cordero M. I., Ansermet F., Sandi C.. ( 2013;). Long-term programming of enhanced aggression by peripuberty stress in female rats. . Psychoneuroendocrinology 38:, 2758–2769. [CrossRef][PubMed]
    [Google Scholar]
  6. Goettelfinger P., Roussin R., Lecerf F., Berrih-Aknin S., Fattal-German M.. ( 2000;). T cell deletion and unresponsiveness induced by intrathymic injection of staphylococcal enterotoxin B. . Transpl Immunol 8:, 39–48. [CrossRef][PubMed]
    [Google Scholar]
  7. Guan J., Liu Y., Kong X., Zhu X., Yu F., Lin N., Liu C., Zhang T.. ( 2012;). [Effect of maternal staphylococcal enterotoxin B administration during pregnancy on CD3+ TCR Vβ8+T cells of adult offspring rats]. . Nan Fang Yi Ke Da Xue Xue Bao 32:, 1230–1233 (in Chinese).[PubMed]
    [Google Scholar]
  8. Jiménez E., Vicente A., Sacedón R., Muñoz J. J., Weinmaster G., Zapata A. G., Varas A.. ( 2001;). Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: a role for the Notch ligand, Jagged1. . J Immunol 166:, 5898–5908. [CrossRef][PubMed]
    [Google Scholar]
  9. Kaplan J. L., Shi H. N., Walker W. A.. ( 2011;). The role of microbes in developmental immunologic programming. . Pediatr Res 69:, 465–472. [CrossRef][PubMed]
    [Google Scholar]
  10. Kawabe Y., Ochi A.. ( 1991;). Programmed cell death and extrathymic reduction of Vbeta8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B. . Nature 349:, 245–248. [CrossRef][PubMed]
    [Google Scholar]
  11. Kelly K. A., Scollay R.. ( 1992;). Seeding of neonatal lymph nodes by T cells and identification of a novel population of CD3-CD4+ cells. . Eur J Immunol 22:, 329–334. [CrossRef][PubMed]
    [Google Scholar]
  12. Kilcoyne K. R., Smith L. B., Atanassova N., Macpherson S., McKinnell C., van den Driesche S., Jobling M. S., Chambers T. J., De Gendt K.. & other authors ( 2014;). Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells. . Proc Natl Acad Sci U S A 111:, E1924–E1932. [CrossRef][PubMed]
    [Google Scholar]
  13. Krow-Lucal E. R., Kim C. C., Burt T. D., McCune J. M.. ( 2014;). Distinct functional programming of human fetal and adult monocytes. . Blood 123:, 1897–1904. [CrossRef][PubMed]
    [Google Scholar]
  14. Li J., Zhou Y. B., Zhang Y., Zhang J., Chen W. F.. ( 2008;). [Cloning deletion of mouse medullary CD4SP thymocyte subgroups induced by superantigen staphylococcal enterotoxin B]. . Beijing Da Xue Xue Bao 40:, 557–561. (in Chinese)[PubMed]
    [Google Scholar]
  15. MacDonald H. R., Baschieri S., Lees R. K.. ( 1991;). Clonal expansion precedes anergy and death of V beta 8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo. . Eur J Immunol 21:, 1963–1966. [CrossRef][PubMed]
    [Google Scholar]
  16. Rellahan B. L., Jones L. A., Kruisbeek A. M., Fry A. M., Matis L. A.. ( 1990;). In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B. . J Exp Med 172:, 1091–1100. [CrossRef][PubMed]
    [Google Scholar]
  17. Ruchat S. M., Hivert M. F., Bouchard L.. ( 2013;). Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus. . Nutr Rev 71: (Suppl. 1), S88–S94. [CrossRef][PubMed]
    [Google Scholar]
  18. Seth A., Stern L. J., Ottenhoff T. H., Engel I., Owen M. J., Lamb J. R., Klausner R. D., Wiley D. C.. ( 1994;). Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro. . Nature 369:, 324–327. [CrossRef][PubMed]
    [Google Scholar]
  19. Vickers M. H.. ( 2014;). Early life nutrition, epigenetics and programming of later life disease. . Nutrients 6:, 2165–2178. [CrossRef][PubMed]
    [Google Scholar]
  20. Webb S., Morris C., Sprent J.. ( 1990;). Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. . Cell 63:, 1249–1256. [CrossRef][PubMed]
    [Google Scholar]
  21. Yang W. X., Zhu X., Yu F. L., Zhang T., Lin N., Liu T. T., Zhao F. F., Liu Y., Xia H., Guan J. C.. ( 2014;). Decreased Vβ8.2 T-cells in neonatal rats exposed prenatally to Staphylococcal enterotoxin B are further deleted by restimulation in an in vitro cultured thymus. . Mol Med Rep 10:, 989–994.[PubMed]
    [Google Scholar]
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