1887

Abstract

Poliomyelitis, a disease which can manifest as muscle paralysis, is caused by the poliovirus, which is a human enterovirus and member of the family that usually transmits by the faecal–oral route. The viruses of the OPV (oral poliovirus attenuated-live vaccine) strains can mutate in the human intestine during replication and some of these mutations can lead to the recovery of serious neurovirulence. Informatics research of the poliovirus genome can be used to explain further the characteristics of this virus. In this study, sequences from 100 poliovirus isolates were acquired from GenBank. To determine the evolutionary relationship between the strains, we compared and analysed the sequences of the complete poliovirus genome and the VP1 region. The reconstructed phylogenetic trees for the complete sequences and the VP1 sequences were both divided into two branches, indicating that the genetic relationships of the whole poliovirus genome and the VP1 sequences are very similar. This branching indicates that the virulence and pathogenicity of poliomyelitis may be associated with the VP1 region. Sequence alignment of the VP1 region revealed numerous mutation sites in which mutation rates of >30 % were detected. In a group of strains recorded in the USA, mutation sites and mutation types were the same and this may be associated with their distribution in the evolutionary tree and their genetic relationship. In conclusion, the genetic evolutionary relationships of poliovirus isolate sequences are determined to a great extent by the VP1 protein, and poliovirus strains located on the same branch of the phylogenetic tree contain the same mutation spots and mutation types. Hence, the genetic characteristics of the VP1 region in the poliovirus genome should be analysed to identify the transmission route of poliovirus and provide the basis of viral immunity development.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.081992-0
2014-12-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jmm/63/12/1724.html?itemId=/content/journal/jmm/10.1099/jmm.0.081992-0&mimeType=html&fmt=ahah

References

  1. Blomqvist S., Savolainen-Kopra C., Paananen A., El Bassioni L., El Maamoon Nasr E. M., Firstova L., Zamiatina N., Kutateladze T., Roivainen M. 2010; Recurrent isolation of poliovirus 3 strains with chimeric capsid protein Vp1 suggests a recombination hot-spot site in Vp1. Virus Res 151:246–251 [View Article][PubMed]
    [Google Scholar]
  2. Blomqvist S., El Bassioni L., El Maamoon Nasr E. M., Paananen A., Kaijalainen S., Asghar H., de Gourville E., Roivainen M. 2012; Detection of imported wild polioviruses and of vaccine-derived polioviruses by environmental surveillance in Egypt. Appl Environ Microbiol 78:5406–5409 [View Article][PubMed]
    [Google Scholar]
  3. Dimitriou T. G., Pliaka V., Kyriakopoulou Z., Ruether I. G., Tsakogiannis D., Fountoucidou P., Gartzonika C., Levidiotou-Stefanou S., Markoulatos P. 2014; PCR assays for the identification of rare recombination types from VP1 to 3D genomic region of vaccine derived poliovirus strains. Mol Cell Probes 28:107–112 [View Article][PubMed]
    [Google Scholar]
  4. Haddad-Boubaker S., Ben Yahia A., Bahri O., Morel V., Balanant J., Delpeyroux F., Triki H. 2008; Genetic features of polioviruses isolated in Tunisia, 1991-2006. J Clin Virol 41:81–86 [View Article][PubMed]
    [Google Scholar]
  5. Iliyasu Z., Nwaze E., Verma H., Mustapha A. O., Weldegebriel G., Gasasira A., Wannemuehler K. A., Pallansch M. A., Gajida A. U.& other authors ( 2014; Survey of poliovirus antibodies in Kano, Northern Nigeria. Vaccine 32:1414–1420 [View Article][PubMed]
    [Google Scholar]
  6. Jiang Y. Y., Huang L. 2010; Survey of immune level of healthy population to poliomyelitis virus in border areas of Guangxi. China Trop Med 10:1018–1020
    [Google Scholar]
  7. John T. J., Jain H., Ravishankar K., Amaresh A., Verma H., Deshpande J., Pallansch M. A., Singh A. P., Sreevatsava M.& other authors ( 2011; Monovalent type 1 oral poliovirus vaccine among infants in India: report of two randomized double-blind controlled clinical trials. Vaccine 29:5793–5801 [View Article][PubMed]
    [Google Scholar]
  8. Kew O., Morris-Glasgow V., Landaverde M., Burns C., Shaw J., Garib Z., André J., Blackman E., Freeman C. J.& other authors ( 2002; Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus. Science 296:356–359 [View Article][PubMed]
    [Google Scholar]
  9. Li J., Zhang L. B., Hou X. H., Zheng H., Fang Y., Minoru H., Akio H. 1996; [Genetic analysis of vaccine polioviruses isolated in China]. Chinese Journal of Virology 12:72–79 (in Chinese)
    [Google Scholar]
  10. Luo H. M., Zhang Y., Wang X. Q., Yu W. Z., Wen N., Yan D. M., Wang H. Q., Wushouer F., Wang H. B.& other authors ( 2013; Identification and control of a poliomyelitis outbreak in Xinjiang, China. N Engl J Med 369:1981–1990 [View Article][PubMed]
    [Google Scholar]
  11. Minor P. 2009; Vaccine-derived poliovirus (VDPV): impact on poliomyelitis eradication. Vaccine 27:2649–2652 [View Article][PubMed]
    [Google Scholar]
  12. Nathanson N., Fine P. 2002; Virology. Poliomyelitis eradication – a dangerous endgame. Science 296:269–270 [View Article][PubMed]
    [Google Scholar]
  13. Odoom J. K., Forrest L., Dunn G., Osei-Kwasi M., Obodai E., Arthur-Quarm J., Barnor J., Minor P. D., Martin J. 2012; Interruption of poliovirus transmission in Ghana: molecular epidemiology of wild-type 1 poliovirus isolated from 1995 to 2008. J Infect Dis 206:1111–1120 [View Article][PubMed]
    [Google Scholar]
  14. Pan W. Y., Cai Z. K., Yang Y.& other authors ( 2006; Study on molecular epidemiology in Fujian Province. China Pub Health 22:60–61
    [Google Scholar]
  15. Pan W., Gao Y., Qin L., Ni W., Liu Z., Yun B., Wang Y., Qi X., Gao H., Wang X. 2012; Genetic diversity and phylogenetic analysis of glycoprotein GP85 of ALV-J isolates from Mainland China between 1999 and 2010: coexistence of two extremely different subgroups in layers. Vet Microbiol 156:205–212 [View Article][PubMed]
    [Google Scholar]
  16. Pastoret P. P. 2010; Human and animal vaccine contaminations. Biologicals 38:332–334 [View Article][PubMed]
    [Google Scholar]
  17. Racaniello V. R. 2006; One hundred years of poliovirus pathogenesis. Virology 344:9–16 [View Article][PubMed]
    [Google Scholar]
  18. Rahimi P., Tabatabaie H., Gouya M. M., Mahmudi M., Musavi T., Rad K. S., Azad T. M., Nategh R. 2009; Direct identification of non-polio enteroviruses in residual paralysis cases by analysis of VP1 sequences. J Clin Virol 45:139–141 [View Article][PubMed]
    [Google Scholar]
  19. Rekand T., Male R., Myking A. O., Nygaard S. J. T., Aarli J. A., Haarr L., Langeland N. 2003; Detection of viral sequences in archival spinal cords from fatal cases of poliomyelitis in 1951-1952. J Virol Methods 114:91–96 [View Article][PubMed]
    [Google Scholar]
  20. Rhoden E., Liu H. M., Wang-Chern S. W., Oberste M. S. 2013; Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination with antiviral capsid inhibitor compounds. Antiviral Res 98:186–191 [View Article][PubMed]
    [Google Scholar]
  21. Roberts J. A., Kuiper M. J., Thorley B. R., Smooker P. M., Hung A. 2012; Investigation of a predicted N-terminal amphipathic α-helix using atomistic molecular dynamics simulation of a complete prototype poliovirus virion. J Mol Graph Model 38:165–173 [View Article][PubMed]
    [Google Scholar]
  22. Schindler C., Fischer W. B. 2012; Sequence alignment of viral channel proteins with cellular ion channels. J Comput Biol 19:1060–1072 [View Article][PubMed]
    [Google Scholar]
  23. Shimazawa R., Ikeda M. 2012; The vaccine gap between Japan and the UK. Health Policy 107:312–317 [View Article][PubMed]
    [Google Scholar]
  24. Smallman-Raynor M., Cliff A. D. 2013; The geographical spread of the 1947 poliomyelitis epidemic in England and Wales: spatial wave propagation of an enigmatic epidemiological event. J Hist Geogr 40:36–51 [View Article]
    [Google Scholar]
  25. Stevens H., Bertelsen M. F., Sijmons S., Van Ranst M., Maes P. 2013; Characterization of a novel polyomavirus isolated from a fibroma on the trunk of an African elephant (Loxodonta africana). PLoS ONE 8:e77884 [View Article][PubMed]
    [Google Scholar]
  26. Tavares F. N., da Costa E. V., Kew O. M., da Silva E. E. 2013; Complete genome sequence of the last representative genotype of wild indigenous poliovirus type 1, which circulated in Brazil. Genome Announc 1:e00811-13 [View Article][PubMed]
    [Google Scholar]
  27. Zhang L. B., Hou X. H., Zhu H.& other authors ( 2010; The circulation and pathogenesis of type 2 recombinant polioviruses in China. China Plan Immunization 6:125–128
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.081992-0
Loading
/content/journal/jmm/10.1099/jmm.0.081992-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error