RT Journal Article SR Electronic(1) A1 Hadrich, Inès A1 Neji, Sourour A1 Makni, Fattouma A1 Ayadi, Ali A1 Elloumi, Moez A1 Ranque, StéphaneYR 2014 T1 Trailing or paradoxical growth of Aspergillus flavus exposed to caspofungin is independent of genotype JF Journal of Medical Microbiology, VO 63 IS 12 SP 1584 OP 1589 DO https://doi.org/10.1099/jmm.0.076000-0 PB Microbiology Society, SN 1473-5644, AB There are limited data on in vitro susceptibility testing of echinocandins against Aspergillus species. The objective of this study was to describe the phenotypes of Aspergillus flavus observed on exposure to caspofungin in vitro and to test whether these phenotypes were associated with A. flavus genotypes. The caspofungin MICs of 37 A. flavus clinical isolates collected from 14 patients with invasive aspergillosis were determined using Etest assays. Caspofungin MICs ranged from 0.012 to 0.064 mg l−1; the modal MIC was 0.023 mg l−1 and the MIC50 and MIC90 were 0.032 and 0.064 mg l−1, respectively. A clear end point was noted in 24 (65 %) isolates, whereas seven (19 %) displayed a trailing effect and six (16 %) showed paradoxical growth when exposed to caspofungin. In these A. flavus isolates, the absence of a significant population structure or genetic differentiation indicated that trailing or paradoxical growth phenotypes were independent of microsatellite genotype., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.076000-0