1887

Abstract

The antifungal activity of the saponin-rich fractions (SFs) from (aerial parts and roots) and (used as a well-known source of plant saponins) against reference and clinical strains, their yeast-to-hyphal conversion, adhesion, and biofilm formation was investigated. Direct fungicidal/fungistatic properties of the tested phytochemicals used alone, as well as their synergy with azoles (probably resulting from yeast cell wall instability) were demonstrated. Here, to the best of our knowledge, we report for the first time the ability of saponin-rich extracts of and to inhibit germ tube formation, limit hyphal growth, reduce yeast adherence and biofilm formation, and eradicate mature (24 h) biofilm. Moreover, SFs (mainly obtained from aerial parts), in the range of concentrations which were active modulators of virulence factors, exhibited low cytotoxicity against the mouse fibroblast line L929. These properties seem to be very promising in the context of using plant-derived SFs as potential novel antifungal therapeutics supporting classic drugs or as ingredients of disinfectants.

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2014-08-01
2021-10-18
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