There are sparse data concerning sex- and age-specific characteristics of community-acquired bacteraemia (CAB) and hospital-acquired bacteraemia (HAB). Between January 2008 and December 2012, we identified 2956 bacteraemia cases, which we classified as CAB, HAB or healthcare-associated bacteraemia (HCAB). Almost half of the pathogens were Escherichia coli in CAB patients. By contrast, Staphylococcus aureus was most frequent (16.2 %) in HAB patients. HCAB showed mixed features of CAB and HAB. In CAB, E. coli was significantly more abundant in females than in males (56.9 vs 24.3 %, respectively). This trend was most striking in young adults (20–39 years) (77.2 % in females vs 11.4 % in males). HAB cases showed greater heterogeneity in their associated pathogens. The extended-spectrum β-lactamase-positive rates of E. coli and Klebsiella pneumoniae, respectively, were 31.3 and 33.8 % in HAB and 8.8 and 8.4 % in CAB. The non-susceptibility rates of S. aureus to oxacillin were 37.4 % in CAB and 73.0 % in HAB. In conclusion, CAB and HAB showed different distributions of micro-organisms, and these distributions also differed with patient age and sex. In addition, antimicrobial susceptibility needs to be monitored separately.
BekerisL. G.,
TworekJ. A.,
WalshM. K.,
ValensteinP. N.2005; Trends in blood culture contamination: a College of American Pathologists Q-Tracks study of 356 institutions. Arch Pathol Lab Med 129:1222–1225[PubMed]
CockerillF. R.III,
WilsonJ. W.,
VetterE. A.,
GoodmanK. M.,
TorgersonC. A.,
HarmsenW. S.,
SchleckC. D.,
IlstrupD. M.,
WashingtonJ. A.II,
WilsonW. R.2004; Optimal testing parameters for blood cultures. Clin Infect Dis 38:1724–1730 [View Article][PubMed]
DeenJ.,
von SeidleinL.,
AndersenF.,
ElleN.,
WhiteN. J.,
LubellY.2012; Community-acquired bacterial bloodstream infections in developing countries in south and southeast Asia: a systematic review. Lancet Infect Dis 12:480–487 [View Article][PubMed]
DouglasM. W.,
LumG.,
RoyJ.,
FisherD. A.,
AnsteyN. M.,
CurrieB. J.2004; Epidemiology of community-acquired and nosocomial bloodstream infections in tropical Australia: a 12-month prospective study. Trop Med Int Health 9:795–804 [View Article][PubMed]
HuhK.,
KimJ.,
ChoS. Y.,
HaY. E.,
JooE. J.,
KangC. I.,
ChungD. R.,
LeeN. Y.,
SongJ. H.other authors2013; Continuous increase of the antimicrobial resistance among gram-negative pathogens causing bacteremia: a nationwide surveillance study by the Korean Network for Study on Infectious Diseases (KONSID). Diagn Microbiol Infect Dis 76:477–482 [View Article][PubMed]
KangC. I.,
KimS. H.,
BangJ. W.,
KimH. B.,
KimN. J.,
KimE. C.,
OhM. D.,
ChoeK. W.2006; Community-acquired versus nosocomial Klebsiella pneumoniae bacteremia: clinical features, treatment outcomes, and clinical implication of antimicrobial resistance. J Korean Med Sci 21:816–822 [View Article][PubMed]
KanoksilM.,
JatapaiA.,
PeacockS. J.,
LimmathurotsakulD.2013; Epidemiology, microbiology and mortality associated with community-acquired bacteremia in northeast Thailand: a multicenter surveillance study. PLoS ONE 8:e54714 [View Article][PubMed]
KimH.-J.,
LeeN. Y.,
KimS.,
ShinJ. H.,
KimM.-N.,
KimE.-C.,
KooS. H.,
RyooN. H.,
KimJ.-S.,
ChoJ.-H.KIm2011; Characteristics of microorganisms isolated from blood cultures at nine university hospitals in Korea during 2009. Korean J Clin Microbiol 14:48–54 [View Article]
Rodríguez-BañoJ.,
López-PrietoM. D.,
PortilloM. M.,
RetamarP.,
NateraC.,
NuñoE.,
HerreroM.,
del ArcoA.,
MuñozA.other authors2010; Epidemiology and clinical features of community-acquired, healthcare-associated and nosocomial bloodstream infections in tertiary-care and community hospitals. Clin Microbiol Infect 16:1408–1413 [View Article][PubMed]
Siegman-IgraY.,
FourerB.,
Orni-WasserlaufR.,
GolanY.,
NoyA.,
SchwartzD.,
GiladiM.2002; Reappraisal of community-acquired bacteremia: a proposal of a new classification for the spectrum of acquisition of bacteremia. Clin Infect Dis 34:1431–1439 [View Article][PubMed]
UslanD. Z.,
CraneS. J.,
SteckelbergJ. M.,
CockerillF. R.III,
St SauverJ. L.,
WilsonW. R.,
BaddourL. M.2007; Age- and sex-associated trends in bloodstream infection: a population-based study in Olmsted County, Minnesota. Arch Intern Med 167:834–839 [View Article][PubMed]
WangJ. L.,
ChenS. Y.,
WangJ. T.,
WuG. H.,
ChiangW. C.,
HsuehP. R.,
ChenY. C.,
ChangS. C.2008; Comparison of both clinical features and mortality risk associated with bacteremia due to community-acquired methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus
. Clin Infect Dis 46:799–806 [View Article][PubMed]
WeinsteinM. P.,
TownsM. L.,
QuarteyS. M.,
MirrettS.,
ReimerL. G.,
ParmigianiG.,
RellerL. B.1997; The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 24:584–602[PubMed][CrossRef]