1887

Abstract

The aim of this study was to compare bacteriological findings in the middle nasal meatus in patients with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) and healthy controls, and to investigate the correlation between the prevalence of culture-identified bacteria and the severity of sinus disease. Bacterial culture was performed using a swab from the middle nasal meatus under endoscopic control in 72 patients with CRSwNP, 25 patients with CRSsNP and 59 healthy controls. Computed tomography (CT) scans were graded for severity using the Lund–Mackay scoring system. Patients with more severe forms of CRS with and without nasal polyps had significantly higher rates of pathogenic bacteria in the middle nasal meatus compared with patients with lower CT scores of the paranasal sinuses. There were no significant differences in bacterial species among CRSwNP, CRSsNP and control patients. These results demonstrate, for the first time, that colonization by pathogenic bacteria in patients with CRSwNP and CRSsNP is associated with a more severe form of the disease, as assessed by a pre-operative CT scan of the paranasal sinuses. The results suggest a role for bacterial infection in the pathogenesis of CRS. However, bacteria do not appear to play a role in the development of nasal polyposis in patients with CRS.

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2014-01-01
2019-12-07
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References

  1. Bhattacharyya N. . ( 2002; ). The role of infection in chronic rhinosinusitis. . Curr Allergy Asthma Rep 2:, 500–506. [CrossRef] [PubMed]
    [Google Scholar]
  2. Bhattacharyya N. , Vyas D. K. , Fechner F. P. , Gliklich R. E. , Metson R. . ( 2001; ). Tissue eosinophilia in chronic sinusitis: quantification techniques. . Arch Otolaryngol Head Neck Surg 127:, 1102–1105. [CrossRef] [PubMed]
    [Google Scholar]
  3. Biel M. A. , Brown C. A. , Levinson R. M. , Garvis G. E. , Paisner H. M. , Sigel M. E. , Tedford T. M. . ( 1998; ). Evaluation of the microbiology of chronic maxillary sinusitis. . Ann Otol Rhinol Laryngol 107:, 942–945.[PubMed] [CrossRef]
    [Google Scholar]
  4. Bolger W. E. . ( 1994; ). Gram negative sinusitis: an emerging clinical entity. ? Am J Rhinol 8:, 279–284. [CrossRef]
    [Google Scholar]
  5. Bousquet J. , Van Cauwenberge P. , Khaltaev N. . Aria Workshop Group World Health Organization ( 2001; ). Allergic rhinitis and its impact on asthma. . J Allergy Clin Immunol 108: (Suppl), S147–S334. [CrossRef] [PubMed]
    [Google Scholar]
  6. Brook I. , Frazier E. H. . ( 2005; ). Bacteriology of chronic maxillary sinusitis associated with nasal polyposis. . J Med Microbiol 54:, 595–597. [CrossRef] [PubMed]
    [Google Scholar]
  7. Fokkens W. J. , Lund V. J. , Mullol J. , Bachert C. , Alobid I. , Baroody F. , Cohen N. , Cervin A. , Douglas R. . & other authors ( 2012; ). EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. . Rhinology 50:, 1–12.[PubMed]
    [Google Scholar]
  8. Hamilos D. L. . ( 2000; ). Chronic sinusitis. . J Allergy Clin Immunol 106:, 213–227. [CrossRef] [PubMed]
    [Google Scholar]
  9. Ikeda K. , Yokoi H. , Kusunoki T. , Saitoh T. , Yao T. , Kase K. , Minekawa A. , Inoshita A. , Kawano K. . ( 2011; ). Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma. . Auris Nasus Larynx 38:, 469–473. [CrossRef] [PubMed]
    [Google Scholar]
  10. Jiang R. S. , Hsu C. Y. , Lin J. F. . ( 1993; ). Comparison of the bacteriologies between the ethmoid and maxillary sinuses in chronic paranasal sinusitis. . J Otolaryngol Soc Roc 28:, 308–317.
    [Google Scholar]
  11. Jiang R. S. , Lin J. F. , Hsu C. Y. . ( 2002; ). Correlation between bacteriology of the middle meatus and ethmoid sinus in chronic sinusitis. . J Laryngol Otol 116:, 443–446. [CrossRef] [PubMed]
    [Google Scholar]
  12. Klossek J. M. , Dubreuil L. , Richet H. , Richet B. , Beutter P. . ( 1998; ). Bacteriology of chronic purulent secretions in chronic rhinosinusitis. . J Laryngol Otol 112:, 1162–1166. [CrossRef] [PubMed]
    [Google Scholar]
  13. Kok J. , Fokkens W. J. , Bachert C. , Toskala E. , Jarvis D. , Bousquet J. , Burney P. . ( 2009; ). The high prevalence of chronic rhinosinusitis in Europe: findings from the GALEN Questionnaire. . Allergy 64:, 1429.[CrossRef]
    [Google Scholar]
  14. Lund V. J. , Mackay I. S. . ( 1993; ). Staging in rhinosinusitus. . Rhinology 31:, 183–184.[PubMed]
    [Google Scholar]
  15. Mantovani K. , Bisanha A. A. , Demarco R. C. , Tamashiro E. , Martinez R. , Anselmo-Lima W. T. . ( 2010; ). Maxillary sinuses microbiology from patients with chronic rhinosinusitis. . Braz J Otorhinolaryngol 76:, 548–551. [CrossRef] [PubMed]
    [Google Scholar]
  16. Nadel D. M. , Lanza D. C. , Kennedy D. W. . ( 1998; ). Endoscopically guided cultures in chronic sinusitis. . Am J Rhinol 12:, 233–241. [CrossRef] [PubMed]
    [Google Scholar]
  17. Niederfuhr A. , Kirsche H. , Riechelmann H. , Wellinghausen N. . ( 2009; ). The bacteriology of chronic rhinosinusitis with and without nasal polyps. . Arch Otolaryngol Head Neck Surg 135:, 131–136. [CrossRef] [PubMed]
    [Google Scholar]
  18. Ozcan M. , Unal A. , Aksaray S. , Yalcin F. , Akdeniz T. . ( 2002; ). Correlation of middle meatus and ethmoid sinus microbiology in patients with chronic sinusitis. . Rhinology 40:, 24–27.[PubMed]
    [Google Scholar]
  19. Settipane G. A. , Chafee F. H. . ( 1977; ). Nasal polyps in asthma and rhinitis. A review of 6,037 patients. . J Allergy Clin Immunol 59:, 17–21. [CrossRef] [PubMed]
    [Google Scholar]
  20. Van Crombruggen K. , Zhang N. , Gevaert P. , Tomassen P. , Bachert C. . ( 2011; ). Pathogenesis of chronic rhinosinusitis: inflammation. . J Allergy Clin Immunol 128:, 728–732. [CrossRef] [PubMed]
    [Google Scholar]
  21. Van Zele T. , Gevaert P. , Watelet J. B. , Claeys G. , Holtappels G. , Claeys C. , van Cauwenberge P. , Bachert C. . ( 2004; ). Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. . J Allergy Clin Immunol 114:, 981–983. [CrossRef] [PubMed]
    [Google Scholar]
  22. Zurak K. , Vagić D. , Drvis P. , Prohaska Potocnik C. , Dzidic S. , Kalogjera L. . ( 2009; ). Bacterial colonization and granulocyte activation in chronic maxillary sinusitis in asthmatics and non-asthmatics. . J Med Microbiol 58:, 1231–1235. [CrossRef] [PubMed]
    [Google Scholar]
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