@article{mbs:/content/journal/jmm/10.1099/jmm.0.068247-0, author = "Lu, Qing-Bin and Wo, Ying and Wang, Hong-Yu and Wei, Mao-Ti and Zhang, Lei and Yang, Hong and Liu, En-Mei and Li, Ting-Yu and Zhao, Zhong-Tang and Liu, Wei and Cao, Wu-Chun", title = "Detection of enterovirus 68 as one of the commonest types of enterovirus found in patients with acute respiratory tract infection in China", journal= "Journal of Medical Microbiology", year = "2014", volume = "63", number = "3", pages = "408-414", doi = "https://doi.org/10.1099/jmm.0.068247-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.068247-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Human enterovirus 68 (HEV-68) is an enterovirus associated with respiratory illness. In China, no information about HEV-68 is available for children yet. This study aimed to investigate the presence of HEV-68 in mainland China between 2009 and 2012 and to explore the migration events of HEV-68 across the world. Among 1565 samples tested from children, 41 (2.6 %) were positive for HEV and 223 (14.3 %) for human rhinovirus (HRV). Seven (17.1 %) of 41 HEVs were HEV-68. Two HEV-68- and five HRV-positive samples were detected in 585 adult samples. HEV-68 is the predominant type of enterovirus in children with acute respiratory tract infection (ARTI), followed by HEV-71 and coxsackievirus A6. Three HEV-68-infected children presented with severe pneumonia and one presented with a severe asthma attack. The viruses were attributed to two novel distinct sublineages of HEV-68 based on phylogenetic analysis of partial VP1 gene sequences. Migration events analysis showed that the USA and the Netherlands were possible geographical sources of HEV-68, from where three strains migrated to China. In conclusion, HEV-68 may play a predominant role among the enteroviruses associated with ARTI in children. Additional surveillance is needed to clarify the reason why HEV-68 causes such a wide spectrum of disease, from asymptomatic to severe respiratory disease and even death.", }