1887

Abstract

We conducted detailed genetic analyses of the haemagglutinin–neuraminidase () gene in 272 human parainfluenza virus type 3 (HPIV3) isolates from children with acute respiratory illness during the period 2002–2009 in Yamagata prefecture, Japan. A phylogenetic tree reconstructed by the Bayesian Markov chain Monte Carlo method showed that the strains diversified at around 1946 and that the rate of molecular evolution was 1.10×10 substitutions per site per year. Identity was high among the present strains (<90 %) and the -distances were short. Furthermore, we found four positive selection sites and some key amino acid substitutions in active/catalytic sites of the HN protein. The results suggest that the gene of HPIV3 in the present strains evolved rapidly, similarly to other virus genes such as the gene of respiratory syncytial virus. However, the biological functions and detailed structures of the HN glycoprotein in some of these strains may have been altered.

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2014-04-01
2019-10-22
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