1887

Abstract

Multilocus sequence typing and antimicrobial susceptibility testing were performed for three community-onset New Delhi metallo-β-lactamase-1 (NDM-1)-producing isolates from Korea. The genetic structure surrounding the gene was determined in -harbouring plasmids. Three NDM-1-producing isolates were found to belong to the same clone (sequence type 340). Each of these isolates showed the same genetic structure surrounding the gene. The genes , , and were flanked by two intact insertion sequences, IS and IS, which may promote horizontal gene transfer. The -harbouring plasmids conferred antimicrobial resistance to carbapenems, cephalosporins, aminoglycosides and aztreonam in transconjugants. It can be speculated that either the entire -harbouring plasmids or just the part of the plasmid containing the gene may have transferred between and . Following the transfer, the isolate disseminated throughout Korea. This study suggests the need for monitoring the dissemination of NDM-1-producing isolates across countries or continents due to their potential transferability via IS and IS-associated transposons.

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2014-01-01
2020-07-07
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