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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 63, Issue 8

Genetic diversity of hepatitis B virus and hepatitis C virus in human immunodeficiency virus type 1-co-infected patients from Venezuela No Access

Abstract

The aim of this study was to evaluate the prevalence and genetic diversity of hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus type 1 (HIV-1)-co-infected Venezuelan patients. The prevalence of HBV and HCV markers of infection in HIV-1 patients was 14 % for anti-hepatitis B core antigen, 3 % for hepatitis B surface antigen and 0.7 % for anti-HCV, respectively. HBV prevalence was higher than HCV, as expected for a country where sexual intercourse, not intravenous drug use, is the main mode of HIV-1 transmission. The HCV genotype distribution in HIV-1-co-infected patients was similar to that obtained in HCV-mono-infected patients, but genotype 1a was more frequent in HIV-1-infected patients. The HBV genotype distribution exhibited differences between mono-infected and HIV-1-co-infected individuals. HBV F3 was the most common subgenotype in both groups, followed by F1b in HIV-1 co-infection and F2 in HBV mono-infection. In addition, genotype G (single infection) was found in an HIV-1-co-infected individual. A high prevalence of occult HBV infection was detected in HIV-1-co-infected naïve patients (18 %), with F2 being the most common genotype (75 %). To the best of our knowledge, these results correspond to the first description of frequency and molecular characterization of HBV and HCV in HIV-1 Venezuelan patients.

  • Received:
  • Accepted:
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© 2014 The Authors
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/content/journal/jmm/10.1099/jmm.0.067496-0
2014-08-01
2025-04-27
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/content/journal/jmm/10.1099/jmm.0.067496-0
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Genetic diversity of hepatitis B virus and hepatitis C virus in human immunodeficiency virus type 1-co-infected patients from Venezuela
J. Med. Microbiol. 63, 1099 (2014); https://doi.org/10.1099/jmm.0.067496-0
/content/journal/jmm/10.1099/jmm.0.067496-0
/content/journal/jmm/10.1099/jmm.0.067496-0
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