1887

Journal of Medical Microbiology logo

Volume 63, Issue 8

Genetic diversity of hepatitis B virus and hepatitis C virus in human immunodeficiency virus type 1-co-infected patients from Venezuela Free

Abstract

The aim of this study was to evaluate the prevalence and genetic diversity of hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus type 1 (HIV-1)-co-infected Venezuelan patients. The prevalence of HBV and HCV markers of infection in HIV-1 patients was 14 % for anti-hepatitis B core antigen, 3 % for hepatitis B surface antigen and 0.7 % for anti-HCV, respectively. HBV prevalence was higher than HCV, as expected for a country where sexual intercourse, not intravenous drug use, is the main mode of HIV-1 transmission. The HCV genotype distribution in HIV-1-co-infected patients was similar to that obtained in HCV-mono-infected patients, but genotype 1a was more frequent in HIV-1-infected patients. The HBV genotype distribution exhibited differences between mono-infected and HIV-1-co-infected individuals. HBV F3 was the most common subgenotype in both groups, followed by F1b in HIV-1 co-infection and F2 in HBV mono-infection. In addition, genotype G (single infection) was found in an HIV-1-co-infected individual. A high prevalence of occult HBV infection was detected in HIV-1-co-infected naïve patients (18 %), with F2 being the most common genotype (75 %). To the best of our knowledge, these results correspond to the first description of frequency and molecular characterization of HBV and HCV in HIV-1 Venezuelan patients.

  • Received:
  • Accepted:
  • Published Online:
© 2014 The Authors
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.067496-0
2014-08-01
2023-12-04
Loading full text...

Full text loading...

/deliver/fulltext/jmm/63/8/1099.html?itemId=/content/journal/jmm/10.1099/jmm.0.067496-0&mimeType=html&fmt=ahah

References

  1. Aguilar M. S., Cosson C., Loureiro C. L., Devesa M., Martínez J., Villegas L., Flores J., Ludert J. E., Alarcón de Noya B. et al. 2001; Prevalence of infection with hepatitis C virus in Venezuela, as assessed with an immuno-assay based on synthetic peptides. Ann Trop Med Parasitol 95:187–195 [View Article][PubMed]
     [Google Scholar]
  2. Allen M. I., Deslauriers M., Andrews C. W., Tipples G. A., Walters K. A., Tyrrell D. L., Brown N., Condreay L. D.Lamivudine Clinical Investigation Group 1998; Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Hepatology 27:1670–1677 [View Article][PubMed]
     [Google Scholar]
  3. Araujo N. M., Branco-Vieira M., Silva A. C., Pilotto J. H., Grinsztejn B., de Almeida A. J., Trepo C., Gomes S. A. 2008; Occult hepatitis B virus infection in HIV-infected patients: evaluation of biochemical, virological and molecular parameters. Hepatol Res 38:1194–1203[PubMed]
     [Google Scholar]
  4. Biswas S., Candotti D., Allain J. P. 2013; Specific amino acid substitutions in the S protein prevent its excretion in vitro and may contribute to occult hepatitis B virus infection. J Virol 87:7882–7892 [View Article][PubMed]
     [Google Scholar]
  5. Cainelli F. 2013; Hepatitis C virus and human immunodeficiency virus transmission routes: Differences and similarities. World J Hepatol 5:234–236 [View Article][PubMed]
     [Google Scholar]
  6. Cardona N. E., Loureiro C. L., Garzaro D. J., Duarte M. C., García D. M., Pacheco M. C., Chemin I., Pujol F. H. 2011; Unusual presentation of hepatitis B serological markers in an Amerindian community of Venezuela with a majority of occult cases. Virol J 8:527–534 [View Article][PubMed]
     [Google Scholar]
  7. Carman W. F., Karayiannis P., Waters J., Thomas H. C., Zanetti A. R., Manzillo G., Zuckerman A. J. 1990; Vaccine-induced escape mutant of hepatitis B virus. Lancet 336:325–329 [View Article][PubMed]
     [Google Scholar]
  8. Chudy M., Schmidt M., Czudai V., Scheiblauer H., Nick S., Mosebach M., Hourfar M. K., Seifried E., Roth W. K. et al. 2006; Hepatitis B virus genotype G monoinfection and its transmission by blood components. Hepatology 44:99–107 [View Article][PubMed]
     [Google Scholar]
  9. Chung R. T. 2006; Hepatitis C and B viruses: the new opportunists in HIV infection. Top HIV Med 14:78–83[PubMed]
     [Google Scholar]
  10. Devesa M., Loureiro C. L., Rivas Y., Monsalve F., Cardona N., Duarte M. C., Poblete F., Gutierrez M. F., Botto C., Pujol F. H. 2008; Subgenotype diversity of hepatitis B virus American genotype F in Amerindians from Venezuela and the general population of Colombia. J Med Virol 80:20–26 [View Article][PubMed]
     [Google Scholar]
  11. El Chaar M., Candotti D., Crowther R. A., Allain J. P. 2010; Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection. Hepatology 52:1600–1610 [View Article][PubMed]
     [Google Scholar]
  12. Gutelius D., Li J., Wands J., Tong S. 2011; Characterization of the pleiotropic effects of the genotype G-specific 36-nucleotide insertion in the context of other hepatitis B virus genotypes. J Virol 85:13278–13289 [View Article][PubMed]
     [Google Scholar]
  13. Gutiérrez C., Devesa M., Loureiro C. L., León G., Liprandi F., Pujol F. H. 2004; Molecular and serological evaluation of surface antigen negative hepatitis B virus infection in blood donors from Venezuela. J Med Virol 73:200–207 [View Article][PubMed]
     [Google Scholar]
  14. Hu X., Margolis H. S., Purcell R. H., Ebert J., Robertson B. H. 2000; Identification of hepatitis B virus indigenous to chimpanzees. Proc Natl Acad Sci U S A 97:1661–1664 [View Article][PubMed]
     [Google Scholar]
  15. Huang C. H., Yuan Q., Chen P. J., Zhang Y. L., Chen C. R., Zheng Q. B., Yeh S. H., Yu H., Xue Y. et al. 2012; Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors. J Hepatol 57:720–729 [View Article][PubMed]
     [Google Scholar]
  16. Jaspe R. C., Sulbarán Y. F., Sulbarán M. Z., Loureiro C. L., Rangel H. R., Pujol F. H. 2012; Prevalence of amino acid mutations in hepatitis C virus core and NS5B regions among Venezuelan viral isolates and comparison with worldwide isolates. Virol J 9:214–221 [View Article][PubMed]
     [Google Scholar]
  17. Kato H., Orito E., Gish R. G., Sugauchi F., Suzuki S., Ueda R., Miyakawa Y., Mizokami M. 2002; Characteristics of hepatitis B virus isolates of genotype G and their phylogenetic differences from the other six genotypes (A through F). J Virol 76:6131–6137 [View Article][PubMed]
     [Google Scholar]
  18. Lemoine M., Nayagam S., Thursz M. 2013; Viral hepatitis in resource-limited countries and access to antiviral therapies: current and future challenges. Future Virol 8:371–380 [View Article][PubMed]
     [Google Scholar]
  19. Machado I. V., del Pilar Fortes M., Vargas-Lovelle B., Trómpiz A. C., López D. A., León R. V., Senior M., Dagher L., López C. E. et al. 2010; Genotype F prevails in Venezuelan urban patients with chronic hepatitis B. Ann Hepatol 9:172–176[PubMed]
     [Google Scholar]
  20. Martínez M. D., Barboza L., Hernández V. R. 2007; Genotypes of hepatitis B: clinical significance. Rev Soc Ven Microbiol 27:349–363 (in Spanish)
    [Google Scholar]
  21. Pereira G. A., Stefani M. M., Martelli C. M., Turchi M. D., Siqueira E. M., Carneiro M. A., Martins R. M. 2006; Human immunodeficiency virus type 1 and hepatitis C virus co-infection and viral subtypes at an HIV testing center in Brazil. J Med Virol 78:719–723 [View Article][PubMed]
     [Google Scholar]
  22. Pozo E., Chaparro M., Padrón A. 2007; Seroprevalence of Hepatitis B in blood donors from Maracaibo Zulia. Period 2000–2005. Kasmera 35:44–55
     [Google Scholar]
  23. Pujol F. H., Loureiro C. L. 2007; Replacement of hepatitis C virus genotype 1b by genotype 2 over a 10-year period in Venezuela. J Clin Gastroenterol 41:518–520 [View Article][PubMed]
     [Google Scholar]
  24. Rangel H. R., Garzaro D., Pujol F. H. 2009; Genetic diversity of human immunodeficiency virus in the Americas, with emphasis on the Venezuelan epidemic. Interciencia 34:163–169 (in Spanish)
    [Google Scholar]
  25. Sucupira M. V., Mello F. C., Santos E. A., Niel C., Rolla V. C., Arabe J., Gomes S. A. 2006; Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations. Mem Inst Oswaldo Cruz 101:655–660 [View Article][PubMed]
     [Google Scholar]
  26. Sulbarán M. Z., Di Lello F. A., Sulbarán Y., Cosson C., Loureiro C. L., Rangel H. R., Cantaloube J. F., Campos R. H., Moratorio G. et al. 2010; Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2. PLoS ONE 5:e14315 [View Article][PubMed]
     [Google Scholar]
  27. Zaaijer H. L., Boot H. J., van Swieten P., Koppelman M. H., Cuypers H. T. 2011; HBsAg-negative mono-infection with hepatitis B virus genotype G. J Viral Hepat 18:815–819 [View Article][PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.067496-0
Loading
Genetic diversity of hepatitis B virus and hepatitis C virus in human immunodeficiency virus type 1-co-infected patients from Venezuela
J. Med. Microbiol. 63, 1099 (2014); https://doi.org/10.1099/jmm.0.067496-0
/content/journal/jmm/10.1099/jmm.0.067496-0
/content/journal/jmm/10.1099/jmm.0.067496-0
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error