1887

Abstract

Markers of intestinal inflammation have been proposed for inclusion in diagnostic algorithms. Faecal calprotectin (f-Cp), a sensitive marker of intestinal inflammation, was evaluated for utility in diagnosis in the hospital setting. One hundred and twenty positive and 99 negative faecal samples of hospital-acquired diarrhoea were analysed for f-Cp using a quantitative ELISA. positivity was confirmed using ELISAs for either toxins ( = 45) or glutamate dehydrogenase (GDH) with toxin gene confirmation ( = 75). Non-parametric ANOVA (Kruskal–Wallis) was used for data analysis. positive samples had higher (<0.05) median (interquartile range) f-Cp levels; 336 µg g (208–536) for toxin and 249 µg g (155–498) for GDH and toxin gene positive compared with 106 µg g (46–176) for and culture-negative faecal samples. Five positive samples were f-Cp negative (<50 µg g). A f-Cp concentration >50 µg g was 96 % sensitive and 26 % specific for , with area under the ROC curve of 0.82. There is no role for f-CP alone in predicting infection in hospital-acquired diarrhoea due to its low specificity.

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2014-04-01
2020-01-27
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